ArticleRSC advances2022
Developing a DNA logic gate nanosensing platform for the detection of acetamiprid.
Article in RSC advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
2 citing papers in PubMed, 7 citations in OpenAlex.
- Programmable DNA aptamer logic gates: from structural design to integrated systems for intelligent nanoscale biosensors.Analytical and bioanalytical chemistry · 2025Review
- Target-driven ratiometric electrochemical aptasensor based on polymerization and AuNP signal amplification for acetamiprid residue determination.Mikrochimica acta · 2025Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This paper reports a novel fluorescence and colorimetric dual-signal-output DNA aptamer based sensor for the detection of acetamiprid residue. Acetamiprid is a new systemic broad-spectrum insecticide with high insecticidal efficiency that is widely used worldwide, but there is a risk of adverse neurological reactions in humans and animals. The dual-mode output principle designed in this paper, consisting of a fluorescence signal and colorimetric signal, is based on the relevant reaction of the special domain of a G-quadruplex, bidding farewell to a classical single-signal output, with a target-recognition cycle used to complete signal amplification through a hybridization chain reaction. Upgraded detection sensitivity and the qualitative and semi-quantitative detection of acetamiprid are achieved based on the fluorescence signal output and visual discrimination observations during colorimetric experiments. This model was applied to the determination of acetamiprid residue in fruits and vegetables. The dual-detection platform further reduced systematic error, with a detection limit of 27.7 pM. When applied in a comparative detection study using three different pesticides, the system shows excellent discrimination specificity and it performs well in actual sample detection and has a fast response time. Designing DNA logic gates that operate in the presence of targets and molecular-switch-based detection platforms also involves the intersection of biology and computational modeling, providing new ideas for biological platforms.
Identifiers
What OpenQuestion holds
Registered trials
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