Evidence map›Paper›PMID 36275878›Full record

ArticleClinical & translational immunology2022

Homologous peptides derived from influenza A, B and C viruses induce variable CD8

Andrea T Nguyen, Hiu Ming Peter Lau, Hannah Sloane, Dhilshan Jayasinghe, Nicole A Mifsud, Demetra Sm Chatzileontiadou, Emma J Grant, Christopher Szeto, Stephanie Gras

Abstract read
In one paragraph

Article in Clinical & translational immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed.

  1. Review
  2. Article
  3. HLA micropolymorphisms confine neoantigen conformational adaptability and guide T cell receptor selectivity.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  4. Assessing CD8Clinical & translational immunology · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. CD8Nature communications · 2024
    Article
  12. Increasing HbA1c is associated with reduced CD8Cellular and molecular life sciences : CMLS · 2024
    Article
  13. Article
  14. CD8Clinical & translational immunology · 2024
    Article
  15. Fighting flu: novel CD8Clinical & translational immunology · 2024
    Review
  16. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Andrea T NguyenDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Hiu Ming Peter LauDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Hannah SloaneDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Dhilshan JayasingheDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Nicole A MifsudDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Demetra Sm ChatzileontiadouDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Emma J GrantDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Christopher SzetoDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.
Stephanie GrasDepartment of Biochemistry and Molecular Biology, Biomedicine Discovery Institute Monash University Clayton VIC Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Influenza A, B and C viruses (IAV, IBV and ICV, respectively) circulate globally, infecting humans and causing widespread morbidity and mortality. Here, we investigate the T cell response towards an immunodominant IAV epitope, NP Methods: We assessed the magnitude (tetramer staining) and quality of the CD8 Results: Our study provides a detailed characterisation of the CD8 Conclusion: We show that while there is a potential to cross-protect against distinct influenza virus lineages, the T cell response was stronger against the IAV peptide than IBV or ICV, which is an important consideration when choosing targets for future vaccine design.

Indexed as

CD8+ T cellcross‐reactivityHLAimmune responseimmunodominant epitopeInfluenza

Identifiers

PMID36275878
PMCPMC9581725

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.