ArticleFrontiers in medicine2022
Depression in non-alcoholic fatty liver disease is associated with an increased risk of complications and mortality.
Article in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 3 of them syntheses that pooled it.
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Who cites it
18 citing papers in PubMed, 3 syntheses or guidelines pooled it, 21 citations in OpenAlex.
- Global research trends on gastrointestinal cancer and mental health (2004-2024): a bibliographic study.Frontiers in medicine · 2025Pooled it
- Causal relationships between neuropsychiatric disorders and nonalcoholic fatty liver disease: A bidirectional Mendelian randomization study.BMC gastroenterology · 2024Pooled it
- Non-alcoholic fatty liver disease and coexisting depression, anxiety and/or stress in adults: a systematic review and meta-analysis.Frontiers in endocrinology · 2024Pooled it
- Metabolic Dysfunction-Associated Steatotic Liver Disease and Risk of Depressive Symptoms in Older Adults.International journal of geriatric psychiatry · 2026Article
- Effects of Hydro-Ethanolic Extract ofHealth science reports · 2026Article
- Weekly Walking Attenuates the Association Between Frailty and Depressive Symptoms in Patients With Rheumatoid Arthritis.Research in nursing & health · 2026Observational
- Causal relationship between obesity, leptin, and brain structure and functional connectivity: evidence based on bidirectional and mediation mendelian randomisation analyses.Nutrition & metabolism · 2026Article
- Multi-Omics Evidence Linking Depression to MASLD Risk via Inflammatory Immune Signaling.Biomedicines · 2026Article
- Psychosocial aspects and mental health burden of pediatric MASLD.Frontiers in endocrinology · 2026Review
- Article
- Obesity drives the link between liver fat and depression: Cross-sectional and prospective investigations.Diabetes, obesity & metabolism · 2025Article
- The Behavioral and Neuroinflammatory Impact of Ketamine in a Murine Model of Depression and Liver Damage.International journal of molecular sciences · 2025Article
- Association between Weight-Adjusted Waist Index and Depression in NAFLD: the modulating roles of sex and BMI.BMC psychiatry · 2024Article
- Article
- Anxiety and depression in metabolic-associated steatotic liver disease: relation with socio-demographic features and liver disease severity.Acta diabetologica · 2024Article
- Moderate Alcohol Consumption Increases the Risk of Clinical Relapse in Male Depressed Patients Treated with Serotonin-Norepinephrine Reuptake Inhibitors.Diagnostics (Basel, Switzerland) · 2024Article
- Non-alcoholic fatty liver disease associated with greater herpes zoster risk than alcoholic fatty liver disease.European journal of medical research · 2023Article
- Antidepressants in People With Chronic Liver Disease and Depression: When Are They Warranted and How to Choose the Suitable One?Journal of clinical and experimental hepatologyReview
Corrections and comments
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Authors and funding
21 authors at 6 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and aims: The global prevalence of non-alcoholic fatty liver disease (NAFLD) is expected to rise continuously. Furthermore, emerging evidence has also shown the potential for concomitant depression in NAFLD. This study aims to examine the prevalence, risk factors, and adverse events of depression in NAFLD and evaluate whether treated depression can reverse the increased risks of adverse outcomes. Materials and methods: This study analyses the 2000-2018 cycles of NHANES that examined liver steatosis with fatty liver index (FLI). The relationship between NAFLD and depression was assessed with a generalized linear mix model and a sensitivity analysis was conducted in the no depression, treated depression, and untreated depression groups. Survival analysis was conducted with cox regression and fine gray sub-distribution model. Results: A total of 21,414 patients were included and 6,726 were diagnosed with NAFLD. The risk of depression in NAFLD was 12% higher compared to non-NAFLD individuals (RR: 1.12, CI: 1.00-1.26, Conclusion: This study shows that concomitant depression in NAFLD patients can increase the risk of adverse outcomes. Early screening of depression in high-risk individuals should be encouraged to improve the wellbeing of NAFLD patients.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.