ReviewFrontiers in medicine2022
Skin scarring: Latest update on objective assessment and optimal management.
Review in Frontiers in medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 27 citations in OpenAlex.
- The Use of Chemical Reconstruction of Skin Scars (CROSS) Method With Trichloroacetic Acid (TCA) for Atrophic Scars: A Comprehensive Review on Application Techniques, Adjunct Therapies, and Complications.The Journal of clinical and aesthetic dermatology · 2026Review
- Racial and Skin Tone Differences in Scar Maturation: A Prospective Analysis of Aesthetic and Physiological Outcomes Using the Modified POSAS Scale.International wound journal · 2026Observational
- Key Outcomes for Evaluating Hand and Wrist Scars: A Nationwide Survey of Clinicians in Saudi Arabia.Medicina (Kaunas, Lithuania) · 2026Article
- How Patients Seek and Value Online Scar-Related Information: A Qualitative Study.European burn journal · 2026Article
- Superior Antiproliferative and Enhanced Synergistic Effects of a ROCK Inhibitor in Multiple Models for Keloid Disease.JID innovations : skin science from molecules to population health · 2025Article
- Therapeutic Potential of Modulating Gene-MicroRNA Crosstalk in Burn Injury.International journal of molecular sciences · 2025Review
- Native Collagen for Surgical Wound and Scar Prevention-A Six-Case Clinical Series.Journal of clinical medicine · 2025Article
- Innovative Rehabilitation of an Anterior Cruciate Ligament Tear in a Football Player: Muscle Chain Approach-A Case Study.Journal of clinical medicine · 2025Article
- Advantages of Mohs Surgery in the Treatment of NMSC in the Head and Neck District.Journal of clinical medicine · 2025Review
- Role of chemistry in nature-inspired skin adhesives.Chemical science · 2025Review
- Mini review on collagens in normal skin and pathological scars: current understanding and future perspective.Frontiers in medicine · 2024Review
- [Pay attention to burn rehabilitation assessment].Zhonghua shao shang yu chuang mian xiu fu za zhi · 2023Article
- Current and Future Developments in Wound Healing.Facial plastic surgery : FPS · 2023Article
- Review
- Article
- Early Patient-Reported Outcomes as Predictors of Long-Term Scar Satisfaction: An Exploratory Cohort Study.Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair SocietyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although skin scarring is considered by some to be a minor, unavoidable consequence in response to skin injury, for many patients, cosmetically unsightly scars may cause uncomfortable symptoms and loss of function plus significant psycho-social distress. Despite their high prevalence and commonality, defining skin scars and their optimal management has proven problematic. Therefore, a literature search to assess the current evidence-base for scarring treatment options was conducted, and only those deemed Levels of Evidence 1 or 2 were included. Understanding the spectrum of skin scarring in the first instance is imperative, and is mainly comprised of four distinct endotypes; Stretched (flat), Contracted, Atrophic, and Raised for which the acronym S.C.A.R. may be used. Traditionally, scar assessment and response to therapy has employed the use of subjective scar scales, although these are now being superseded by non-invasive, objective and quantitative measurement devices. Treatment options will vary depending on the specific scar endotype, but fall under one of 3 main categories: (1) Leave alone, (2) Non-invasive, (3) Invasive management. Non-invasive (mostly topical) management of skin scarring remains the most accessible, as many formulations are over-the-counter, and include silicone-based, onion extract-based, and green tea-based, however out of the 52 studies identified, only 28 had statistically significant positive outcomes. Invasive treatment options includes intralesional injections with steroids, 5-FU, PDT, and laser with surgical scar excision as a last resort especially in keloid scar management unless combined with an appropriate adjuvant therapy. In summary, scar management is a rapidly changing field with an unmet need to date for a structured and validated approach.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.