Evidence map›Paper›PMID 36275778›Full record

ArticleFrontiers in immunology2022

Inducible general knockout of Runx3 profoundly reduces pulmonary cytotoxic CD8

Qin Hao, Suman Kundu, Sreerama Shetty, Torry A Tucker, Steven Idell, Hua Tang

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.3field-weighted citation impact, top 49% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 4 citations in OpenAlex.

  1. AARS1-Mediated RUNX3 K193 Lactylation Enhances the Activation and Cytotoxicity of CD8Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  2. Review
  3. Article
  4. Review
  5. Runx3 Regulates CD8International journal of molecular sciences · 2024
    Article
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Qin HaoDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Suman KunduDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Sreerama ShettyDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Torry A TuckerDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Steven IdellDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
Hua TangDepartment of Cellular and Molecular Biology, The University of Texas Health Science Center at Tyler, Tyler, TX, United States.
The University of Texas Health Science Center at Tyler · US

Funding

Myocardin in the pathogenesis of pleural remodelingR01HL142853 · NHLBI · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI IDELL, STEVEN, IKEBE, MITSUO · 2019 to 2022
$1.9M
The Role of Runx3 in Host Response to Influenza Virus InfectionR21AI128442 · NIAID · UNIVERSITY OF TEXAS HLTH CTR AT TYLER · PI TANG, HUA · 2018 to 2019
$390k
NHLBI NIH HHS R01 HL142853NIAID NIH HHS R21 AI128442
6 · The paper itself

Abstract

Respiratory viruses pose a continuing and substantive threat to human health globally. Host innate and adaptive immune responses are the critical antiviral defense mechanisms to control viral replication and spread. The present study is designed to determine the role of transcription factor Runx3 in the host immune response to influenza A virus (IAV) infection. As Runx3 is required for embryonic development, we generated an inducible

Indexed as

Influenza A virusInfluenza, HumanOrthomyxoviridae InfectionsAnimalsAntiviral AgentsCD8-Positive T-LymphocytesCore Binding Factor Alpha 3 SubunitCytokinesDisease Models, AnimalLungMiceMice, Inbred C57BLMice, KnockoutTranscription FactorsAntiviral AgentsCore Binding Factor Alpha 3 SubunitCytokinesRunx3 protein, humanRunx3 protein, mouseTranscription FactorsCD8+ T cellsdendritic cellsinfluenzalungmacrophagesRunx3

Identifiers

PMID36275778
PMCPMC9586250
OpenAlexW4303045079

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.