Evidence map›Paper›PMID 36275689›Full record

ReviewFrontiers in immunology2022

Development and function of regulatory innate lymphoid cells.

Christopher M Thomas, R Stokes Peebles

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.7field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. (Multi-) omics studies of ILC2s in inflammation and metabolic diseases.Frontiers in cell and developmental biology · 2024
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Christopher M ThomasDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
R Stokes PeeblesDivision of Allergy, Pulmonary, and Critical Care Medicine, Vanderbilt University Medical Center, Nashville, TN, United States.
Vanderbilt University Medical Center · US

Funding

Viral and Host Determinants of Infant and Childhood Allergy and AsthmaU19AI095227 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI Christian Rosas-Salazar · 2011 to 2026
$34.9M
PGI2 augments Treg functionR01AI145265 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEBLES, RAY STOKES · 2019 to 2023
$2.7M
GLP-1R signaling in allergic inflammationR01AI124456 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI NISWENDER, KEVIN D, PEEBLES, RAY STOKES · 2017 to 2021
$2.2M
Host genetics of allergen-induced lung TSLP expression and ILC2 functionR21AI145397 · NIAID · VANDERBILT UNIVERSITY MEDICAL CENTER · PI PEEBLES, RAY STOKES · 2019 to 2020
$468k
PGI2 regulation of CD4+ Th2 metabolism in allergic airway inflammationI01BX004299 · VA · VETERANS HEALTH ADMINISTRATION · PI PEEBLES, RAY STOKES · 2019 to 2025
–
BLRD VA I01 BX004299NIAID NIH HHS R01 AI124456NIAID NIH HHS R01 AI145265NIAID NIH HHS R21 AI145397NIAID NIH HHS U19 AI095227
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are a critical element of the innate immune system and are potent producers of pro-inflammatory cytokines. Recently, however, the production of the anti-inflammatory cytokine IL-10 has been observed in all ILC subtypes (ILC1s, ILC2s, and ILC3s) suggesting their ability to adopt a regulatory phenotype that serves to maintain lung and gut homeostasis. Other studies advocate a potential therapeutic role of these IL-10-expressing ILCs in allergic diseases such as asthma, colitis, and pancreatic islet allograft rejection. Herein, we review IL-10 producing ILCs, discussing their development, function, regulation, and immunotherapeutic potential through suppressing harmful inflammatory responses. Furthermore, we address inconsistencies in the literature regarding these regulatory IL-10 producing ILCs, as well as directions for future research.

Indexed as

AsthmaImmunity, InnateCytokinesHumansInterleukin-10LymphocytesCytokinesInterleukin-10cellIL-10innatelymphoidregulatory

Identifiers

PMID36275689
PMCPMC9581395
OpenAlexW4301585072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.