Evidence map›Paper›PMID 36275673›Full record

ReviewFrontiers in immunology2022

Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis.

Christoph Brieske, Peter Lamprecht, Anja Kerstein-Staehle

Open access · goldAbstract readReview
In one paragraph

Review in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 14 citations in OpenAlex.

  1. Article
  2. Immature leukocyte and plasma-induced cell death reveal subclinical immune activation in EGPA patients in remission.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Christoph BrieskeDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Peter LamprechtDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
Anja Kerstein-StaehleDepartment of Rheumatology and Clinical Immunology, University of Lübeck, Lübeck, Germany.
University of Lübeck · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cell death and dysregulated clearance of dead cells play essential roles in the induction of chronic inflammatory processes and autoimmune diseases. Granulomatosis with polyangiitis (GPA), a neutrophil-driven autoimmune disorder, is characterized by necrotizing inflammation predominantly of the respiratory tract and an anti-neutrophil cytoplasmic autoantibody (ANCA)-associated systemic necrotizing vasculitis. Defective regulation of neutrophil homeostasis and cell death mechanisms have been demonstrated in GPA. Disturbed efferocytosis (

Indexed as

Autoimmune DiseasesGranulomatosis with PolyangiitisHMGB1 ProteinLeukocyte DisordersAntibodies, Antineutrophil CytoplasmicAutoimmunityHumansImmunogenic Cell DeathInflammationAntibodies, Antineutrophil CytoplasmicHMGB1 Proteinautoimmunitydamage-associated molecular pattern (DAMP)granulomatosis with polyangiitisimmunogenic cell deathneutrophilsvasculitis

Identifiers

PMID36275673
PMCPMC9583010
OpenAlexW4302287268

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.