Evidence map›Paper›PMID 36275665›Full record

SynthesisFrontiers in immunology2022

Prognostic impact of the controlling nutritional status score in patients with hematologic malignancies: A systematic review and meta-analysis.

Chuanyang Lu, Qiuni Chen, Linrong Fei, Junhui Wang, Chunling Wang, Liang Yu

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Frontiers in immunology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers, 7 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 7 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 7 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Chuanyang LuDepartment of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Qiuni ChenDepartment of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Linrong FeiDepartment of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Junhui WangThe Huaian Clinical College of Xuzhou Medical University, Huaian, China.
Chunling WangDepartment of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.
Liang YuDepartment of Hematology, The Affiliated Huaian No.1 People's Hospital of Nanjing Medical University, Huaian, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: An increasing number of studies have validated the prognostic significance of the controlling nutritional status (CONUT) score in patients with solid tumors. However, the extent of the correlation between the CONUT score and clinical outcomes of patients with hematologic malignancies is unclear. Objective: This study aimed to investigate the prognostic role of the CONUT score in patients with hematologic malignancies. Methods: All relevant articles published up to November 15, 2021, were identified by systematically searching PubMed, Embase, Web of Science, and Cochrane Library. Pooled hazard ratios (HRs) and 95% confidence intervals were used to quantitatively analyze the association between the CONUT scores and clinical outcomes of patients with hematologic malignancies. Subgroup and sensitivity analyses were performed. Funnel plots as well as Begg's and Egger's tests were used to assess publication bias. Results: Six studies with 1811 patients were included in the meta-analysis. The results showed that a high CONUT score was associated with worse overall survival (OS) (HR=1.34, 95%CI 1.14-1.59, P < 0.001) and progression-free survival (PFS) (HR=1.20, 95%CI 1.10-1.32, P < 0.001). Conclusions: The CONUT score is an independent prognostic factor in patients with hematologic malignancies. Systematic review registration: http://www.crd.york.ac.uk/prospero/, identifier CRD42021292621.

Indexed as

Hematologic NeoplasmsNeoplasmsHumansNutritional StatusPrognosisProportional Hazards Modelscontrolling nutritional status (CONUT) scorehematologic malignancyoverall survival (OS)prognosisprogression-free survival (PFS)

Identifiers

PMID36275665
PMCPMC9581295

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.