ArticleAnimal cells and systems2022
Bioactive peptides in the pancreatin-hydrolysates of whey protein support cell proliferation and scavenge reactive oxygen species.
Article in Animal cells and systems, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Dual-Phase Immunomodulation by the Bovine β-Casein Peptide KEMPFPK: Insights into Potential TLR Interaction and Gut Microbiota-Mediated Effects.Foods (Basel, Switzerland) · 2026Article
- Antioxidant and Antiproliferative Activities of Hemp Seed Proteins (International journal of molecular sciences · 2025Article
- The Promotion of Cell Proliferation by Food-Derived Bioactive Peptides: Sources and Mechanisms.Metabolites · 2025Review
- Optimizing Sleep in Athletes: The Potential of α-Lactalbumin in Nutrition Intervention.Protein and peptide letters · 2025Review
- Jackfruit Leaf Protein Hydrolysates Obtained by Enzymatic Hydrolysis of Leaf Protein Concentrate with Pepsin and Pancreatin: Molecular Weight, Cytotoxicity, Antiproliferative Activity, and Oxidative Stress.Plant foods for human nutrition (Dordrecht, Netherlands) · 2024Article
- Gender-specific alteration of steroid metabolism and its impact on viral replication in a mouse model of hepatitis B virus infection.Animal cells and systems · 2024Article
- Anti-obesity and immunomodulatory effects of oil and fermented extract dried fromAnimal cells and systems · 2024Article
- Effect of Milk Origin and Seasonality of Yogurt Acid Whey on Antioxidant Activity before and after In Vitro Gastrointestinal Digestion.Antioxidants (Basel, Switzerland) · 2023Article
- Internal ribosomal entry site-mediated translational activity of nitric oxide synthase 2.Animal cells and systems · 2023Article
- Chloromethylisothiazolinone induces ER stress-induced stress granule formation in human keratinocytes.Animal cells and systems · 2023Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Whey protein (WP) in milk shows physiologically active functions such as cholesterol control and immune system strengthening. In this study, we performed hydrolysis and peptide polarity fractionation to enhance the efficacy and diversity of its physiological activities, using the digesting enzyme, pancreatin. Our results indicate that hydrolysis significantly increased the cell proliferation of the WP fractions, with the lower-polarity fractions showing greater efficacy in this regard. Our results indicate that hydrolysis significantly increases cell proliferation of the WP fractions. Additionally, we confirmed differences in the antioxidant activity of the WP fractions as a function of polarity was confirmed via scavenging 2,2'-azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assay
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