Evidence map›Paper›PMID 36275132›Full record

ArticleJournal of radiosurgery and SBRT2022

Factors associated with the use of salvage whole brain radiation therapy versus salvage stereotactic radiosurgery after initial stereotactic radiosurgery for brain metastases.

Yash S Soni, Benjamin J Rich, Deukwoo Kwon, Wei Zhao, Danny L John, Crystal Seldon, Jessica Meshman, Ronald Benveniste, Ricardo J Komotar, Macarena de la Fuente and 5 more

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in Journal of radiosurgery and SBRT, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 1 institution in 1 country.

Yash S SoniUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Benjamin J RichDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Deukwoo KwonDepartment of Public Health Sciences, Biostatistics and Bioinformatics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Wei ZhaoDepartment of Public Health Sciences, Biostatistics and Bioinformatics Shared Resource, Sylvester Comprehensive Cancer Center, University of Miami Miller School of Medicine, Miami, FL, USA.
Danny L JohnUniversity of Miami Miller School of Medicine, Miami, FL, USA.
Crystal SeldonDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Jessica MeshmanDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Ronald BenvenisteDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Ricardo J KomotarDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Macarena de la FuenteDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Maria Del Pilar Guillermo PrietoDepartment of Neurology, University of Miami Miller School of Medicine, Miami, FL, USA.
Gregory AzzamDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Eric A MellonDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
Carolina G BenjaminDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Tejan DiwanjiDepartment of Radiation Oncology, University of Miami Miller School of Medicine, Miami, FL, USA.
University of Miami · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objectives: Patients undergoing stereotactic radiosurgery (SRS) for brain metastases require additional radiation for relapse. Our objective is to determine the factors associated with salvage SRS versus whole brain radiation therapy (WBRT) for salvage of first intracranial failure (ICF) after upfront SRS. Method: We identified a cohort of 110 patients with brain metastases treated with SRS in the definitive or postoperative setting followed by subsequent salvage WBRT or SRS at least one month after initial SRS. Clinical and demographic characteristics were retrospectively recorded. Results: 78 Patients received SRS and 32 patients received WBRT at the time of first ICF. On multivariate analysis (MVA) factors associated with decreased use of salvage SRS were male gender (p=0.044) and local progression (p<0.001). Conclusions: Local progression and male gender were the strongest factors associated with selection of salvage WBRT. Possible etiologies of this difference could be provider or patient driven, but warrant further exploration.

Indexed as

brain metastasesdisparitiessalvage radiationStereotactic radiosurgerywhole brain radiation

Identifiers

PMID36275132
PMCPMC9489072
OpenAlexW4307230002

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.