ArticleFrontiers in pediatrics2022
Etiology and clinical characteristics of neonatal sepsis in different medical setting models: A retrospective multi-center study.
Article in Frontiers in pediatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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4 citing papers in PubMed, 5 citations in OpenAlex.
- Risk Factors and Outcomes of Extensively Drug-Resistant Gram-Negative Bacilli in Neonates with Late-Onset Sepsis.Antibiotics (Basel, Switzerland) · 2026Article
- Article
- Analysis of Staphylococcal Diversity in the Skin Microbiota of Healthy Riding Horses.Antibiotics (Basel, Switzerland) · 2025Article
- Early-onset neonatal sepsis in a Chinese maternal and child healthcare centre, 2017-2023.Frontiers in pediatrics · 2025Article
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Authors and funding
13 authors at 6 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Objective: General hospitals admit lower gestational age neonates than maternal and child health care centers, therefore associated with a higher morbidity and mortality. This study aimed to assess the etiology and clinical characteristics of neonatal sepsis in different medical setting models. Methods: Neonates admitted to 5 tertiary medical centers, including one national general hospital, two maternal and child health care hospitals and two regional general hospitals, in central-south China with culture-proven sepsis between January 2010 and December 2019 were included in the study. We compared maternal and neonatal characteristics, pathogen distribution, treatment and neonatal outcomes among 3 different medical setting models in this retrospective cohort. Results: We identified 757 episodes of culture-proven sepsis in 757 neonates. The predominant pathogens were coagulase-negative staphylococci, Conclusion: We report distinct patterns of clinical characteristics, pathogens and outcomes in patient subgroups with neonatal sepsis from national general hospital, maternal and child health care hospital and regional general hospital. It might have some implications for improvement of prevention, management and empirical antibiotic use in neonatal sepsis in different setting models, especially in resource-limited settings from middle and low-income countries.
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