ArticleFrontiers in cellular and infection microbiology2022
Improved accuracy of etiological diagnosis of spinal infection by metagenomic next-generation sequencing.
Article in Frontiers in cellular and infection microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 3 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 3 syntheses or guidelines pooled it, 23 citations in OpenAlex.
- Comparative diagnostic performance of metagenomic next-generation sequencing and conventional microbial culture in spinal infections: a systematic review and meta-analysis.Frontiers in cellular and infection microbiology · 2026Pooled it
- Metagenomic next-generation sequencing (mNGS) versus tissue culture technique (TCT) in diagnosis of spinal infection: a systematic review and meta-analysis.Scientific reports · 2025Pooled it
- What Is the Accuracy of 16S PCR Followed by Sanger Sequencing or Next-generation Sequencing in Native Vertebral Osteomyelitis? A Systematic Review and Meta-analysis.Clinical orthopaedics and related research · 2025Pooled it
- Recommendations of the International Consensus Meeting (ICM) 2025 on Spinal Infections: Part A Pyogenic Spondylodiscitis.Global spine journal · 2026Article
- Vertebral infection after kyphoplasty: distinguishing misdiagnosis from true postoperative infection and implications for management.Journal of orthopaedic surgery and research · 2026Article
- The diagnostic value of metagenomic next-generation sequencing versus traditional microbiological testing in native pyogenic spinal infections: A systematic review and meta-analysis.North American Spine Society journal · 2026Review
- C-arm-guided percutaneous biopsy combined with mNGS: a dual-modality strategy for optimizing diagnosis and targeted management of spinal infections.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2026Review
- Direct pedicle screw fixation in infected vertebrae for acute pyogenic spondylitis: short-term outcomes from a single-arm retrospective study.Frontiers in cellular and infection microbiology · 2026Article
- Integrating metagenomic next-generation sequencing into a multimodal diagnostic framework for spinal infection: enhancing etiological identification and clinical prediction.Frontiers in cellular and infection microbiology · 2026Article
- Clinical application value of nanopore-targeted sequencing technology for primary spine infection: a mulicenter, retrospective observational study.BMC infectious diseases · 2025Observational
- Progress in diagnosis and treatment of primary spondylodiscitis: a systematic literature review.EFORT open reviews · 2025Article
- Pathogen Detection in Spinal Infections: Next-Generation Sequencing Versus Conventional Microbiological Methods.Current medical science · 2025Article
- The application of endoscopic debridement combined with metagenomic next-generation sequencing technology in primary spinal infections: a retrospective study.Journal of orthopaedic surgery and research · 2025Article
- Observational
- The application value of targeted next-generation sequencing in the diagnosis of primary osteoarticular infections: A single-center study.Frontiers in cellular and infection microbiology · 2025Article
- The clinical management and efficacy of metagenomic next-generation sequencing in patients with pyogenic spinal infection: a single-center cohort study.Journal of orthopaedic surgery and research · 2024Article
- Standardized naming of microbiome samples in Genomes OnLine Database.Database : the journal of biological databases and curation · 2023Article
- Analysis of risk factors for deep vein thrombosis after spinal infection surgery and construction of a nomogram preoperative prediction model.Frontiers in cellular and infection microbiology · 2023Article
- Diagnostic Efficacy of Metagenomic Next-Generation Sequencing in Patients with Spinal Infections: A Retrospective Study.Infection and drug resistance · 2023Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Currently, the use of metagenomic next-generation sequencing (mNGS), a new approach to identify organisms in infectious diseases, is rarely reported in the diagnosis of spinal infection. This study aimed to evaluate the potential value of mNGS in etiological diagnosis of spinal infection. In this retrospective study, the clinical data of patients with suspected spinal infection were collected by electronic medical records. Specimens obtained from each patient were tested
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.