Evidence map›Paper›PMID 36274959›Full record

ArticleiScience2022

D2R signaling in striatal spiny neurons modulates L-DOPA induced dyskinesia.

Ermanno Florio, Marcello Serra, Robert G Lewis, Enikö Kramár, Michael Freidberg, Marcello Wood, Micaela Morelli, Emiliana Borrelli

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 9 citations in OpenAlex.

  1. Indirect Striatal Projection Neurons Drive a D2 Receptor-Dependent Pathway to Dyskinesia and Dystonia.Movement disorders : official journal of the Movement Disorder Society · 2026
    Article
  2. Article
  3. Levodopa-induced dyskinesia: brain iron deposition as a new hypothesis.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Ermanno FlorioDepartment of Microbiology & Molecular Genetics, INSERM U1233, Center for Epigenetics and Metabolism, 308 Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA.
Marcello SerraDepartment of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato (CA), Italy.
Robert G LewisDepartment of Microbiology & Molecular Genetics, INSERM U1233, Center for Epigenetics and Metabolism, 308 Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA.
Enikö KramárDepartment of Neurobiology and Behavior, University of California, Irvine, 200 Qureshey Research Lab., Irvine, CA 92697, USA.
Michael FreidbergDepartment of Chemistry, University of California, Irvine, 1102 Natural Sciences II, Irvine, CA 92697, USA.
Marcello WoodDepartment of Neurobiology and Behavior, University of California, Irvine, 200 Qureshey Research Lab., Irvine, CA 92697, USA.
Micaela MorelliDepartment of Biomedical Sciences, Section of Neuroscience, University of Cagliari, Cittadella Universitaria di Monserrato, 09042 Monserrato (CA), Italy.
Emiliana BorrelliDepartment of Microbiology & Molecular Genetics, INSERM U1233, Center for Epigenetics and Metabolism, 308 Sprague Hall, University of California, Irvine, Irvine, CA 92697, USA.
University of California, Irvine · USUniversity of Cagliari · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Degeneration of dopaminergic neurons leads to Parkinson's disease (PD), characterized by reduced levels of striatal dopamine (DA) and impaired voluntary movements. DA replacement is achieved by levodopa treatment which in long-term causes involuntary movements or dyskinesia. Dyskinesia is linked to the pulsatile activation of D1 receptors of the striatal medium spiny neurons (MSNs) forming the direct output pathway (dMSNs). The contribution of DA stimulation of D2R in MSNs of the indirect pathway (iMSNs) is less clear. Using the 6-hydroxydopamine model of PD, here we show that loss of DA-mediated inhibition of these neurons intensifies levodopa-induced dyskinesia (LID) leading to reprogramming of striatal gene expression. We propose that the motor impairments characteristic of PD and of its therapy are critically dependent on D2R-mediated iMSNs activity. D2R signaling not only filters inputs to the striatum but also indirectly regulates dMSNs mediated responses.

Indexed as

Behavioral neuroscienceBiological sciencesNeuroscienceTranscriptomics

Identifiers

PMID36274959
PMCPMC9579025
OpenAlexW4300772614

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.