ArticleJournal of inflammation research2022
Dynamic Status of SII and SIRI Alters the Risk of Cardiovascular Diseases: Evidence from Kailuan Cohort Study.
Article in Journal of inflammation research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 64 citations in OpenAlex.
- Association Between Life's Crucial 9 and the prevalence of coronary heart disease in U.S. adults: the potential role of the systemic inflammatory response index.BMC cardiovascular disorders · 2026Article
- Predictive Value of Composite Inflammatory Markers for Stroke Prognosis: A Prospective Cohort Study.Annals of clinical and translational neurology · 2026Article
- Association of systemic inflammatory response index (SIRI) with clinical outcomes in hemodialysis patients: a single-center observational study.BMC nephrology · 2026Observational
- Systemic inflammation and mental health: A J-shaped dose-response pattern in depression based on NHANES 2005 to 2018.Medicine · 2026Article
- Systemic Inflammatory Indices Predict Survival and Limb Outcomes after Revascularization for Chronic Limb-Threatening Ischemia.Journal of vascular research · 2026Article
- Association of nine composite inflammatory indices with cardiovascular diseases in US adults: national health and nutrition examination survey (NHANES, 2005-2018).Journal of health, population, and nutrition · 2026Article
- Association between pathological stages and grades of chorioamnionitis and neonatal myocardial injury: a nested case-control study within a retrospective cohort.Frontiers in medicine · 2026Article
- Machine learning based on systemic inflammation response index and risk of cardiovascular disease in gout: a retrospective study and clinical validation.Clinical rheumatology · 2026Article
- Inflammatory and metabolic markers mediate the association of hepatic steatosis and fibrosis with 10-year ASCVD risk.Annals of medicine · 2025Article
- Threshold effect of systemic immune-response index on in-stent neoatherosclerosis among patients with drug-eluting stent restenosis.European journal of medical research · 2025Article
- The Relationship Between Myocardial Fibrosis in Hypertensive Patients With Preserved Ejection Fraction and the Severity of Systemic Inflammatory Status Is Mediated by Epicardial Adipose Tissue: A Multicenter Cohort Study.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Predictive value of systemic inflammation response index for atherosclerotic cardiovascular disease risk in patients with hypercholesterolemia: a machine learning study with dual-cohort validation.Lipids in health and disease · 2025Article
- Effects of statins on major adverse cardiovascular events, metabolic and inflammatory parameters in patients with hepatitis B virus comorbid with cardiovascular disease.Cardiovascular diagnosis and therapy · 2025Article
- Relationship between aggregate index of systemic inflammation and mortality from CCD and malignant neoplasms in diabetic patients.Scientific reports · 2025Article
- Epigenetic age acceleration mediates the association between low-grade systemic inflammation and cardiovascular diseases: insight from the NHANES 1999-2002.Clinical epigenetics · 2025Article
- A nomogram risk prediction model for ischemic mitral regurgitation after primary percutaneous coronary intervention in patients with ST-segment elevation myocardial infarction.European journal of medical research · 2025Article
- Association between the atherogenic index of plasma and the systemic immuno-inflammatory index using NHANES data from 2005 to 2018.Scientific reports · 2025Article
- Association between the systemic inflammatory response index and acute ischemic stroke in young people.Frontiers in neurology · 2025Article
- Article
- Association between stroke and systemic inflammation response index (SIRI): a National Health and Nutrition Examination Survey (NHANES) Study 2015-2020.BMJ neurology open · 2025Article
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Authors and funding
10 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Two novel systemic inflammation indices, SII and SIRI, are associated with increased risk of cardiovascular diseases (CVD). However, SII and SIRI are prone to change over time and the association between changeable status and long-term outcome risk remains to be uncovered. This study aims to examine the association between the dynamic status of SII and SIRI and risk of CVD. Methods: This prospective study included a total of 45,809 subjects without MI, stroke and cancer prior to or in 2010 (baseline of this study). The dynamic status of SII and SIRI during 2006, 2008, and 2010 was assessed by dynamic trajectories (primary exposure), annual increase, and average value. The outcome was CVD incidence during 8.6 years' follow-up. Multiple Cox regression models were used to calculate the adjusted hazard ratios (HRs) and confidence intervals (95% CIs). Results: Four dynamic trajectories of SII and SIRI were identified as follows: low stable pattern, moderate stable pattern, increase pattern, and decrease pattern. For SII, compared with "low stable pattern", after controlling confounders and level of SII in 2006, adjusted HRs were 1.24 (95% CI = 1.02-1.51) for "increase pattern" and 1.11 (95% CI = 1.00-1.23) for "moderate-stable pattern" while the association was not significant for "decrease pattern". Additionally, the highest group of annual SII increase and average SII had respective HR of 1.20 (95% CI = 1.05-1.37) and 1.32 (95% CI = 1.13-1.55). The results were consistent for SIRI. "Increase pattern" and "moderate stable pattern" increased the risk of CVD by 38% (HR = 1.38, 95% CI = 1.17-1.63) and 12% (HR = 1.12, 95% CI = 1.01-1.25), while no significant association was found for "decrease pattern". The highest group of annual SIRI increase and average SIRI had respective HR of 1.25 (95% CI = 1.09-1.44) and 1.39 (95% CI = 1.19-1.63). Conclusion: Dynamic status of SII and SIRI was significantly associated with risk of CVD, which highlighted that we should focus on the dynamic change of SII and SIRI.
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