Evidence map›Paper›PMID 36274693›Full record

ArticleFrontiers in microbiology2022

Glyphosate and its formulations Roundup Bioflow and RangerPro alter bacterial and fungal community composition in the rat caecum microbiome.

Robin Mesnage, Simona Panzacchi, Emma Bourne, Charles A Mein, Melissa J Perry, Jianzhong Hu, Jia Chen, Daniele Mandrioli, Fiorella Belpoggi, Michael N Antoniou

Open access · goldAbstract read
In one paragraph

Article in Frontiers in microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 32 citations in OpenAlex.

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  12. Impact of glyphosate (RoundupGut microbes · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 6 institutions in 3 countries.

Robin MesnageDepartment of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, Gene Expression and Therapy Group, King's College London, Guy's Hospital, London, United Kingdom.
Simona PanzacchiRamazzini Institute, Bologna, Italy.
Emma BourneGenome Centre, Barts and the London School of Medicine and Dentistry, Blizard Institute, London, United Kingdom.
Charles A MeinGenome Centre, Barts and the London School of Medicine and Dentistry, Blizard Institute, London, United Kingdom.
Melissa J PerryDepartment of Environmental and Occupational Health, Milken Institute School of Public Health, George Washington University, Washington, DC, United States.
Jianzhong HuDepartment of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Jia ChenDepartment of Environmental Medicine and Public Heath, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Daniele MandrioliRamazzini Institute, Bologna, Italy.
Fiorella BelpoggiRamazzini Institute, Bologna, Italy.
Michael N AntoniouDepartment of Medical and Molecular Genetics, Faculty of Life Sciences and Medicine, Gene Expression and Therapy Group, King's College London, Guy's Hospital, London, United Kingdom.
Istituto Ramazzini · ITIcahn School of Medicine at Mount Sinai · USQueen Mary University of London · GBGuy's Hospital · GBKing's College London · GBMilken Institute · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The potential health consequences of glyphosate-induced gut microbiome alterations have become a matter of intense debate. As part of a multifaceted study investigating toxicity, carcinogenicity and multigenerational effects of glyphosate and its commercial herbicide formulations, we assessed changes in bacterial and fungal populations in the caecum microbiota of rats exposed prenatally until adulthood (13 weeks after weaning) to three doses of glyphosate (0.5, 5, 50 mg/kg body weight/day), or to the formulated herbicide products Roundup Bioflow and RangerPro at the same glyphosate-equivalent doses. Caecum bacterial microbiota were evaluated by 16S rRNA sequencing whilst the fungal population was determined by ITS2 amplicon sequencing. Results showed that both fungal and bacterial diversity were affected by the Roundup formulations in a dose-dependent manner, whilst glyphosate alone significantly altered only bacterial diversity. At taxa level, a reduction in Bacteroidota abundance, marked by alterations in the levels of

Indexed as

glyphosatemicrobiota (16S)mycobiomepesticidestoxicity

Identifiers

PMID36274693
PMCPMC9580462
OpenAlexW4302007720

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.