Evidence map›Paper›PMID 36274680›Full record

ArticleRegenerative therapy2022

Bridging potential of Taurine-loading PCL conduits transplanted with hEnSCs on resected sciatic nerves.

Arman Ai, Jamileh Saremi, Somayeh Ebrahimi-Barough, Narges Fereydouni, Tara Mahmoodi, Nastaran Kazemi Rad, Pedram Sarikhani, Arash Goodarzi, Fardin Amidi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Regenerative therapy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Arman AiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Jamileh SaremiResearch Center for Noncommunicable Diseases, Jahrom University of Medical Sciences, Jahrom, Iran.
Somayeh Ebrahimi-BaroughDepartment of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Narges FereydouniDepartment of Tissue engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Tara MahmoodiSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Nastaran Kazemi RadSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Pedram SarikhaniSchool of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Arash GoodarziDepartment of Tissue engineering, School of Medicine, Fasa University of Medical Sciences, Fasa, Iran.
Fardin AmidiDepartment of Anatomy, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.
Tehran University of Medical Sciences · IRFasa University of Medical Sciences · IRJahrom University of Medical Sciences · IR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reconstruction of nerve conduits is a promising method for functional improvement in peripheral nerve repair. Besides choosing of a suitable polymer for conduit construction, adding factors such as Taurine improve a more advantageous microenvironment for defect nerve regeneration. Showing several major biological properties of Taurine, for example, regulation of the osmotic pressure, modulation of neurogenesis, and calcium hemostasis, makes it an appropriate option for repairing of defected nerves. To this, we examined repairing effects of Taurine-loading PCL conduits cultured with human endothelial stem cells (hEnSCs) on resected sciatic nerves. PCL/Taurine/Cell conduits transplanted to a 10-mm sciatic nerve gap. Forty-two wistar rats were randomly divided to seven groups: (1) Normal group, (2) Negative control (NC), (3) Positive control (nerve Autograft group), (4) PCL conduits group (PCL), (5) Taurine loaded PCL conduits group (PCL/Taurine), (6) hEnSCs cultured on the PCL conduits (PCL/Cell), (7) hEnSCs cultured on the PCL/Taurine conduits (PCL/Taurine/Cell). Functional recovery of motor and sensory nerves, the action potential of exciting muscle and motor distal latency has seen in PCL/Taurine/Cell conduits. Histological studies showed also remarkable nerve regeneration and obvious bridging has seen in this group. In conclusion, PCL/Taurine/Cell conduits showing suitable mechanical properties and biocompatibility may improve sciatic nerve regeneration.

Indexed as

AD, Alzheimer's diseaseDAPI, diamidino phenylindoleDPN, peripheral neuropathyECM, extracellular matrix structureEMAP, muscle action potentialEMG, electromyographyFBS, fetal bovine serumFDA, Food and Drug AdministrationhEnSCs, human endothelial stem cellsHPF, high power fieldsHPL, hotplate latencyHuman endothelial stem cells (hEnSCs)LFB, Luxol fast blueMSCs, mesenchymal stem cellsMTT, dimethylthiazol diphenyl tetrazolium bromideNerve regenerationNGC, nerve guidance conduitsPBS, phosphate-buffered salinePCL, polycaprolactonePD, Parkinson's diseasePNS, peripheral nerve systemSFI, sciatic functionl indexTaurineTCP, tissue culture plateWRL, withdrawal reflex latency

Identifiers

PMID36274680
PMCPMC9556906
OpenAlexW4304140222

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.