ArticleESC heart failure2023
Long-term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction.
Article in ESC heart failure, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Article
- Observational
- Observational
- Charlson comorbidity Index for descriptive risk stratification of long-term All-cause mortality in elderly patients with acute myocardial infarction: a retrospective cohort study.Frontiers in cardiovascular medicine · 2026Article
- Comparisons of three-year outcomes according to the degree of left ventricular ejection fraction in patients with myocardial infarction with non-ST-segment elevation with and without chronic kidney disease.Cardiology journal · 2026Article
- Long-term prognostic impact of one-year change in left ventricular function after a myocardial infarction: insights from the REBUS cohort.European heart journal. Imaging methods and practice · 2026Article
- Development and validation of a long-term mortality prediction model in acute coronary syndrome survivors: a study of a predominantly male, lower-risk cohort with the capacity to complete cardiopulmonary exercise testing.BMC cardiovascular disorders · 2025Article
- Cancer as a novel risk factor for major cardiovascular adverse events in secondary prevention.International journal of cardiology. Cardiovascular risk and prevention · 2025Article
- Impact of diabetes and ejection fraction on non-ST-Segment elevation myocardial infarction outcomes.Heart and vessels · 2025Article
- Effect of previous stroke on quality of inpatient care and long-term mortality risk of non-ST-segment myocardial infarction.European heart journal open · 2025Article
- Proposed NT-ProBNP Threshold for Predicting 2-Year Heart Failure Mortality and Implications for Long-Term Community Follow-Up.Epidemiologia (Basel, Switzerland) · 2025Article
- Plasma extracellular vesicle cargo microRNAs are associated with heart failure and cardiovascular death following acute coronary syndrome.Extracellular vesicle · 2025Article
- Observational
- Anemia, Hyperglycemia, and Reduced Left Ventricular Ejection Fraction Improve the GRACE Score's Predictability for In-hospital Mortality in Acute Coronary Syndrome; Single-Centre Cross-Sectional Study.Open access emergency medicine : OAEM · 2025Article
- Comparison of Outcomes Between ST-Segment Elevation and Non-ST-Segment Elevation Myocardial Infarctions Based on Left Ventricular Ejection Fraction.Journal of clinical medicine · 2024Article
- Cardiac Magnetic Resonance Imaging Based Ischemic Injury Pattern in Patients with Acute Myocardial Infarction Sensu Left Ventricular Global Systolic Function.Diagnostics (Basel, Switzerland) · 2024Article
- Long-term mortality after acute coronary syndromes among patients with normal, mildly reduced, or reduced ejection fraction.ESC heart failure · 2023Article
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16 authors.
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No grant is acknowledged in the PubMed record.
Abstract
aimsLeft ventricular ejection fraction (LVEF) ≤ 40% is a well-established risk factor for mortality after acute coronary syndromes (ACS). However, the long-term prognostic impact of mildly reduced ejection fraction (EF) (LVEF 41-49%) after ACS remains less clear. METHODS AND
resultsThis was a retrospective study enrolling patients admitted with ACS included in a single-centre databank. LVEF was assessed by echocardiography during index hospitalization. Patients were divided in the following categories according to LVEF: normal (LVEF ≥ 50%), mildly reduced (LVEF 41-49%), and reduced (LVEF ≤ 40%). The endpoint of interest was all-cause death after hospital discharge. A multivariable Cox model was used to adjust for confounders. A total of 3200 patients were included (1952 with normal EF, 375 with mildly reduced EF, and 873 with reduced EF). The estimated cumulative incidence rates of mortality at 10 years for patients with normal, mildly reduced, and reduced EF were 24.8%, 33.5%, and 41.3%, respectively. After adjustments, the presence of reduced EF was associated with higher mortality compared with normal EF [adjusted hazard ratio (HR) 1.64; 95% confidence interval (CI) 1.36-1.96; P < 0.001], as was mildly reduced EF compared with normal EF (adjusted HR 1.33; 95% CI 1.05-1.68; P = 0.019). The presence of reduced EF was not associated with a statistically significantly higher mortality compared with mildly reduced EF (adjusted HR 1.23; 95% CI 0.96-1.57; P = 0.095).
conclusionsIn patients with ACS, mildly reduced EF measured in the acute phase was associated with higher long-term mortality compared with patients with normal EF. These data emphasize the importance of anti-remodelling therapies for ACS patients who have LVEF in the mildly reduced range.
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