ArticleMedical science monitor : international medical journal of experimental and clinical research2022
Effect of Antilogous Platelet-Rich Plasma on the Revascularization of Rabbit Prefabricated Flap.
Article in Medical science monitor : international medical journal of experimental and clinical research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed.
- Effects of platelet-rich plasma on cutaneous flap healing in rabbits: a pilot comparative experimental study with adipose tissue.Scientific reports · 2026Article
- Study of the effects and mechanism of allogeneic platelet-rich plasma gel on layered skin flaps.Scientific reports · 2025Article
- Enhanced Pain Relief and Function Improvement in Children with Osgood-Schlatter Disease: Leukocyte-Rich Platelet-Rich Plasma (LR-PRP) as a Complementary Treatment to Standard Conservative Therapy.Medical science monitor : international medical journal of experimental and clinical research · 2023Article
- The Autonomization Principle in Vascularized Flaps: An Alternative Strategy for Composite Tissue Scaffold In Vivo Revascularization.Bioengineering (Basel, Switzerland) · 2023Review
- Gluteal Propeller Perforator Flaps: A Paradigm Shift in Abdominoperineal Amputation Reconstruction.Journal of clinical medicine · 2023Article
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND We aimed to investigate the effect of the local application of autologous platelet-rich plasma (PRP) on the angiogenesis of the rabbit prefabricated flap. MATERIAL AND METHODS Femoral arteriovenous bundle prefabricated flaps were constructed on both sides of the abdomen of 20 New Zealand white rabbits and were randomly divided into experimental sides and control sides, with 40 sides in total. Autologous PRP was injected around the prefabricated femoral vascular bundle on the experimental side, and the same amount of saline was injected on the control side. After 14 days, stage II surgery was performed to lift the island flap with the implanted femoral vascular bundle at the tip of the preconfigured flap marker line and suture it in situ. Twenty rabbits were divided equally into 4 groups: group A, 7 days after stage I surgery; group B, 14 days after stage I surgery; group C, 7 days after stage II surgery; and group D, 14 days after stage II surgery. The survival of neovascularization and the flaps in the 4 groups were compared by microscopic observation, histology, and immunohistochemistry. RESULTS The density of neovascularization was much higher on the experimental side than on the control side in the 4 groups, and statistically significantly increased with time (P<0.05). Seven days after stage II surgery, flap survival was better on the experimental side than on the control side. CONCLUSIONS PRP effectively promoted the revascularization of a prefabricated flap, and vascular density increased with time.
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