SynthesisCritical care (London, England)2022
Effects of rapid fluid infusion on hemoglobin concentration: a systematic review and meta-analysis.
Synthesis in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Variation in central venous oxygen saturation to evaluate fluid responsiveness: a systematic review and meta-analysis.Critical care (London, England) · 2023Pooled it
- Trial
- Effect of an Integrated Early Enteral Nutrition Management Protocol on Nutritional Target Attainment in Mechanically Ventilated ICU Patients: A Quasi-Experimental Study Guided by the MRC Framework.Nursing in critical care · 2026Article
- Effects of postural change and mobilization on hemoglobin levels in ICU patients: a prospective intervention study.Intensive care medicine experimental · 2026Article
- Sex-Specific Temporal Patterns of Haemoglobin and Haematocrit as Mortality Predictors in Polytrauma Patients: A Watson Trauma Pathway Explorer Analysis.Journal of clinical medicine · 2026Article
- Article
- Prognostic Implications of Hemoglobin Drop With and Without Overt Bleeding After Percutaneous Coronary Intervention.JACC. Asia · 2025Article
- Use of COAnnals of intensive care · 2025Review
- A predictive model for prognosis in infants with surgical necrotizing enterocolitis.Italian journal of pediatrics · 2025Article
- Sepsis-induced cardiomyopathy: understanding pathophysiology and clinical implications.Archives of toxicology · 2025Review
- Variations in central venous oxygen saturation and central venous-to-arterial carbon dioxide tension difference to define fluid responsiveness: a prospective observational study.Frontiers in cardiovascular medicine · 2025Article
- New insights in fluid monitoring for surgical patients. A concept study.Frontiers in medical technology · 2025Article
- A model to simulate human cardio-respiratory responses to different fluid resuscitation treatments after hemorrhagic injury.Frontiers in physiology · 2025Article
- Association between hemoglobin and in-hospital mortality in critically ill patients with sepsis: evidence from two large databases.BMC infectious diseases · 2024Article
- Changes in central venous-to-arterial PCOCritical care (London, England) · 2024Article
- Influence of an iron dextran injection in various diseases on hematological blood parameters, including serum ferritin, neonatal dairy calves.BMC veterinary research · 2024Article
- Evaluating the efficacy of a standardized 4 mL/kg fluid bolus technique in critically ill patients with elevated PFrontiers in medicine · 2024Article
- Prognostic impact of in-hospital hemoglobin decline in non-overt bleeding ICU patients with acute myocardial infarction.BMC cardiovascular disorders · 2023Article
- Inpatient Metabolic Panel Trajectories Improve 6-Month Mortality Prognostication after Severe Traumatic Brain Injury.Neurotrauma reportsArticle
- Oxygen delivery, hemodilution and transfusion in critical illness: an underrecognized safety signal in albumin randomized trials.Blood transfusion = Trasfusione del sangueArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRapid fluid administration may decrease hemoglobin concentration (Hb) by a diluting effect, which could limit the increase in oxygen delivery (DO
methodsOur protocol was registered in PROSPERO (CRD42020165146). We searched PubMed, the Cochrane Database, and Embase from inception until February 15, 2022. We selected studies that reported Hb before and after rapid fluid administration (bolus fluid given over less than 120 min) with crystalloids and/or colloids in adults. Exclusion criteria were studies that included bleeding patients, or used transfusions or extracorporeal circulation procedures. Studies were divided according to whether they involved non-acutely ill or acutely ill (surgical/trauma, sepsis, circulatory shock or severe hypovolemia, and mixed conditions) subjects. The mean Hb difference and, where reported, the DO
resultsSixty-five studies met our inclusion criteria (40 in non-acutely ill and 25 in acutely ill subjects), with a total of 2794 participants. Risk of bias was assessed as "low" for randomized controlled trials (RCTs) and 'low to moderate' for non-RCTs. Across 63 studies suitable for meta-analysis, the Hb decreased significantly by a mean of 1.33 g/dL [95% CI - 1.45 to - 1.12; p < 0.001; I
conclusionsHb decreased consistently after rapid fluid administration with moderate certainty of evidence. This effect may limit the positive effects of fluid challenges on DO
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.