Evidence map›Paper›PMID 36274111›Full record

ArticleAnalytical and bioanalytical chemistry2023

Icosahedral gold nanoparticles decorated with hexon protein: a surrogate for adenovirus serotype 5.

Beatriz Fresco-Cala, Ángela I López-Lorente, Alex D Batista, Mehmet Dinc, Joachim Bansmann, R Jürgen Behm, Soledad Cárdenas, Boris Mizaikoff

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical and bioanalytical chemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 2 countries.

Beatriz Fresco-CalaInstitute of Analytical and Bioanalytical Chemistry, Ulm University, 89081, Ulm, Germany. q72frcab@uco.es.
Ángela I López-LorenteDepartamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUNAN, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, E-14071, Córdoba, España.
Alex D BatistaInstitute of Analytical and Bioanalytical Chemistry, Ulm University, 89081, Ulm, Germany. alex.domingues-batista@uni-ulm.de.
Mehmet Dinc, Hahn-Schickard, 89077, Ulm, Germany.
Joachim BansmannInstitute for Surface Chemistry and Catalysis, Ulm University, 89081, Ulm, Germany.
R Jürgen BehmInstitute for Surface Chemistry and Catalysis, Ulm University, 89081, Ulm, Germany.
Soledad CárdenasDepartamento de Química Analítica, Instituto Universitario de Investigación en Química Fina y Nanoquímica IUNAN, Universidad de Córdoba, Campus de Rabanales, Edificio Marie Curie, E-14071, Córdoba, España.
Boris MizaikoffInstitute of Analytical and Bioanalytical Chemistry, Ulm University, 89081, Ulm, Germany.
Universität Ulm · DEUniversity of Córdoba · ESHahn-Schickard-Gesellschaft für angewandte Forschung · DE

Funding

Financial Support Programmes for Female Researchers, Office for Gender Equality (Ulm University, Germany). Surrogate-imprinted polymer filters for improved wMinisterium für Wissenschaft, Forschung und Kunst (MWK) Baden-Württemberg within the specific funding line 'Research on Covid-19'. 'Research on Covid-19'.
6 · The paper itself

Abstract

The development of synthetic particles that emulate real viruses in size, shape, and chemical composition is vital to the development of imprinted polymer-based sorbent materials (molecularly imprinted polymers, MIPs). In this study, we address surrogates for adenovirus type 5 (Adv 5) via the synthesis and subsequent modification of icosahedral gold nanoparticles (iAuNPs) decorated with the most abundant protein of the Adv 5 (i.e., hexon protein) at the surface. CTAB-capped iAuNPs with dimensions in the range of 40-90 nm were synthesized, and then CTAB was replaced by a variety of polyethylene glycols (PEGs) in order to introduce suitable functionalities serving as anchoring points for the attachment of the hexon protein. The latter was achieved by non-covalent linking of the protein to the iAuNP surface using a PEG without reactive termination (i.e., methoxy PEG thiol, mPEG-SH, Mn=800). Alternatively, covalent anchoring points were generated by modifying the iAuNPs with a bifunctional PEG (i.e., thiol PEG amine, SH-PEG-NH

Indexed as

GoldMetal NanoparticlesAdenoviridaeCetrimoniumGlutaralPolyethylene GlycolsPolymersSerogroupSulfhydryl CompoundsCetrimoniumGlutaralGoldmonomethoxypolyethylene glycolPolyethylene GlycolsPolymersSulfhydryl CompoundsAdenovirus serotype 5Hexon-imprinted polymerHexon proteinIcosahedral gold nanoparticlesPEGylationSurrogate

Identifiers

PMID36274111
PMCPMC9589707
OpenAlexW4307122980

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.