Evidence map›Paper›PMID 36273868›Full record

ArticleJournal of neurosurgery. Case lessons2022

Xenotransplantation of porcine progenitor cells in an epileptic California sea lion (Zalophus californianus): illustrative case.

Claire A Simeone, John P Andrews, Shawn P Johnson, Mariana Casalia, Ryan Kochanski, Edward F Chang, Dianne Cameron, Sophie Dennison, Ben Inglis, Gregory Scott and 11 more

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neurosurgery. Case lessons, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.6field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 6 institutions in 1 country.

Claire A Simeone1Sea Change Health, Kentfield, California.
John P Andrews3Department of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California.
Shawn P Johnson1Sea Change Health, Kentfield, California.
Mariana Casalia3Department of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California.
Ryan Kochanski3Department of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California.
Edward F Chang3Department of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California.
Dianne Cameron2Six Flags Discovery Kingdom, Vallejo, California.
Sophie Dennison4TeleVet Imaging Solutions, Oakton, Virginia.
Ben Inglis5Henry H. Wheeler, Jr. Brain Imaging Center, University of California, Berkeley, Berkeley, California.
Gregory Scott2Six Flags Discovery Kingdom, Vallejo, California.
Kris Kruse-Elliott6Sage Veterinary Centers, Redwood City, California.
F Fabian Okonski7Department of Anesthesiology, Perioperative and Pain Medicine, Lucile Packard Children's Hospital at Stanford, Stanford School of Medicine, Stanford, California.
Eric Calvo2Six Flags Discovery Kingdom, Vallejo, California.
Kelly Goulet2Six Flags Discovery Kingdom, Vallejo, California.
Dawn Robles2Six Flags Discovery Kingdom, Vallejo, California.
Ashley Griffin-Stence2Six Flags Discovery Kingdom, Vallejo, California.
Erin Kuiper2Six Flags Discovery Kingdom, Vallejo, California.
Laura Krasovec8BrainLab, Westchester, Illinois.
Cara L Field9The Marine Mammal Center, Sausalito, California; and.
Vanessa F Hoard10Pacific Marine Mammal Center, Laguna Beach, California.
Scott C Baraban3Department of Neurological Surgery & Weill Institute for Neuroscience, University of California, San Francisco, San Francisco, California.
Neurological Surgery · USMarine Mammal Center · USUniversity of California, San Francisco · USLucile Packard Children's Hospital · USTeledyne Technologies (United States) · USUniversity of California, Berkeley · US

Funding

An Interneuron-based Cell Therapy for EpilepsyR01NS071785 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI Scott C Baraban · 2010 to 2026
$5.1M
NINDS NIH HHS R01 NS071785
6 · The paper itself

Abstract

backgroundDomoic acid (DA) is a naturally occurring neurotoxin harmful to marine animals and humans. California sea lions exposed to DA in prey during algal blooms along the Pacific coast exhibit significant neurological symptoms, including epilepsy with hippocampal atrophy. OBSERVATIONS: Here the authors describe a xenotransplantation procedure to deliver interneuron progenitor cells into the damaged hippocampus of an epileptic sea lion with suspected DA toxicosis. The sea lion has had no evidence of seizures after the procedure, and clinical measures of well-being, including weight and feeding habits, have stabilized. LESSONS: These preliminary results suggest xenotransplantation has improved the quality of life for this animal and holds tremendous therapeutic promise.

Indexed as

domoic acid toxicosisepilepsyepilepsy xenograftinterneuron progenitor cellsMGE progenitor cellssea lion

Identifiers

PMID36273868
PMCPMC9379678
OpenAlexW4220745293

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.