ArticleJournal of neuro-oncology2022
Ventricular entry during surgical resection is associated with intracranial leptomeningeal dissemination in glioblastoma patients.
Article in Journal of neuro-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.
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Who cites it
13 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Long-term outcomes of ventricular entry in high grade glioma resection: A meta-Analysis and meta regression.Neurosurgical review · 2026Pooled it
- Article
- Leptomeningeal metastases at recurrence in IDH-wildtype glioblastomas: incidence, risk factors, and prognosis based on postcontrast FLAIR imaging.European radiology · 2025Article
- Ependymal invasion in High-Grade Glioma. Impact on surgical, functional outcomes, and survival rates. Experience in a Latin-American center.Neurosurgical review · 2025Article
- Article
- Effectiveness and safety of Tachosil® as a ventricular sealant: an observational cohort study.Acta neurochirurgica · 2024Observational
- The Impact of Lateral Ventricular Opening in the Resection of Newly Diagnosed High-Grade Gliomas: A Single Center Experience.Cancers · 2024Article
- Article
- Distant recurrence in the cerebellar dentate nucleus through the dentato-rubro-thalamo-cortical pathway in supratentorial glioma cases.Acta neurochirurgica · 2024Article
- Individualized survival prediction and surgery recommendation for patients with glioblastoma.Frontiers in medicine · 2024Article
- Imaging-tracked progression of primary leptomeningeal gliomatosis: A case report.Surgical neurology international · 2024Article
- Leptomeningeal spread in high-grade gliomas: Is surgery or adjuvant therapy after leptomeningeal spread associated with survival benefit?Neurosurgical review · 2023Article
- Intensive multimodal ketogenic metabolic therapy in glioblastoma: A clinical trial.Neuro-oncology advancesArticle
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Authors and funding
5 authors at 1 institution in 1 country.
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Abstract
purposeGlioblastoma (GBM) is associated with a poorer prognosis when leptomeningeal dissemination (LMD) occurs. Recently, the role of both ventricular entry (VE) during surgery and subventricular zone localization of tumors in promoting LMD in GBM patients has been debated. This article investigates the role of VE in causing LMD in GBM patients.
methodsWe conducted a retrospective analysis of GBMs operated on at our Institution between March 2018 and December 2020. We collected pre- and post-surgical images, anamnestic information, and surgical reports.
resultsTwo hundred cases were collected. The GBM localization was periventricular in 69.5% of cases, and there was a VE during the surgical procedure in 51% of cases. The risk of post-surgical LMD in the case of VE was 16%. The rate of LMD was higher in the case of VE than not-VE (27.4% vs. 4%, p < 0.0001). The rate of LMD in periventricular GBM was 19% (p = 0.1131).
conclusionAccording to our data, VE is an independent factor associated with a higher rate of post-surgical LMD, and the periventricular localization is not independently correlated to this negative outcome. Neurosurgeons should avoid VE when possible. The correct surgical strategy should be founded on balancing the need for maximal EOR and the risks associated with VE.
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