ArticleNature communications2022
Reward salience but not spatial attention dominates the value representation in the orbitofrontal cortex.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 16 citations in OpenAlex.
- Control of associative learning by the mediodorsal thalamus-orbitofrontal cortex circuit.Nature communications · 2026Article
- Orbitofrontal-sensory cortical interactions in learning and adaptive decision-making.Trends in cognitive sciences · 2026Review
- Associations between trajectories of plasma biomarkers for Alzheimer's disease, brain structures, and cognitive function: a prospective cohort study in the UK Biobank.Molecular psychiatry · 2026Article
- Apathy linked to higher amyloid burden and cognitive deterioration in Parkinson's disease.Journal of Parkinson's disease · 2025Observational
- Brain structures and their association with executive and attentional abilities in very preterm 8-year-old children.Brain structure & function · 2025Article
- Orbitofrontal High-Gamma Reflects Spike-Dissociable Value and Decision Mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Gaze-centered gating, reactivation, and reevaluation of economic value in orbitofrontal cortex.Nature communications · 2024Article
- Sensory over-responsivity and atypical neural responses to socially relevant stimuli in autism.Autism research : official journal of the International Society for Autism Research · 2024Article
- Defining theNature. Mental health · 2024Article
- Distinct roles of the orbitofrontal cortex, ventral striatum, and dopamine neurons in counterfactual thinking of decision outcomes.Science advances · 2023Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The orbitofrontal cortex (OFC) encodes value and plays a key role in value-based decision-making. However, the attentional modulation of the OFC's value encoding is poorly understood. We trained two monkeys to detect a luminance change at a cued location between a pair of visual stimuli, which were over-trained pictures associated with different amounts of juice reward and, thus, different reward salience. Both the monkeys' behavior and the dorsolateral prefrontal cortex neuronal activities indicated that the monkeys actively directed their spatial attention toward the cued stimulus during the task. However, the OFC's neuronal responses were dominated by the stimulus with higher reward salience and encoded its value. The value of the less salient stimulus was only weakly represented regardless of spatial attention. The results demonstrate that reward and spatial attention are distinctly represented in the prefrontal cortex and the OFC maintains a stable representation of reward salience minimally affected by attention.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.