Evidence map›Paper›PMID 36273210›Full record

ArticleTrials2022

Home-based intensive treatment of chronic radiation-associated dysphagia in head and neck cancer survivors (HIT-CRAD trial).

Hanne Massonet, Ann Goeleven, Leen Van den Steen, Alice Vergauwen, Margot Baudelet, Gilles Van Haesendonck, Olivier Vanderveken, Heleen Bollen, Lisette van der Molen, Fréderic Duprez and 3 more

Open access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Longitudinal correlations of subjective, functional, and objective voice parameters following radiotherapy for early glottic carcinoma.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2026
    Article
  3. Review
  4. Dysphagia Advances in Head and Neck Cancer.Current otorhinolaryngology reports · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 2 countries.

Hanne MassonetFaculty of Medicine, Department of Neurosciences, Research Group Experimental Oto-Rhino-Laryngology - Delgutology, KU Leuven, Leuven, Belgium. hanne.massonet@kuleuven.be.ORCID http://orcid.org/0000-0001-6331-9738
Ann GoelevenFaculty of Medicine, Department of Neurosciences, Research Group Experimental Oto-Rhino-Laryngology - Delgutology, KU Leuven, Leuven, Belgium.
Leen Van den SteenFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Alice VergauwenDepartment of Otolaryngology and Head and Neck Surgery, Rehabilitation Centre for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium.
Margot BaudeletDepartment of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
Gilles Van HaesendonckDepartment of Otolaryngology and Head and Neck Surgery, Rehabilitation Centre for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium.
Olivier VandervekenDepartment of Otolaryngology and Head and Neck Surgery, Rehabilitation Centre for Communication Disorders, Antwerp University Hospital, Antwerp, Belgium.
Heleen BollenDepartment of Oncology, University Hospitals Leuven, Leuven, Belgium.
Lisette van der MolenDepartment of Head and Neck Oncology and Surgery, The Netherlands Cancer Institute, Amsterdam, The Netherlands.
Fréderic DuprezDepartment of Radiation Oncology, Ghent University Hospital, Ghent, Belgium.
Peter TomassenDepartment of Head and Neck Surgery, Ghent University Hospital, Ghent, Belgium.
Sandra NuytsDepartment of Oncology, University Hospitals Leuven, Leuven, Belgium.
Gwen Van NuffelenFaculty of Medicine and Health Sciences, University of Antwerp, Antwerp, Belgium.
Antwerp University Hospital · BEGhent University Hospital · BEKU Leuven · BEUniversity of Antwerp · BEThe Netherlands Cancer Institute · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic radiation-associated dysphagia (C-RAD) is considered to be one of the most severe functional impairments in head and neck cancer survivors treated with radiation (RT) or chemoradiation (CRT). Given the major impact of these late toxicities on patients' health and quality of life, there is a strong need for evidence-based dysphagia management. Although studies report the benefit of strengthening exercises, transference of changes in muscle strength to changes in swallowing function often remains limited. Therefore, combining isolated strengthening exercises with functional training in patients with C-RAD may lead to greater functional gains.

methodsThis 3-arm multicenter randomized trial aims to compare the efficacy and possible detraining effects of mere strengthening exercises (group 1) with a combination of strengthening exercises and functional swallowing therapy (group 2) and non-invasive brain stimulation added to that combination (group 3) in 105 patients with C-RAD. Patients will be evaluated before and during therapy and 4 weeks after the last therapy session by means of swallowing-related and strength measures and quality of life questionnaires. DISCUSSION: Overall, this innovative RCT is expected to provide new insights into the rehabilitation of C-RAD to optimize post-treatment swallowing function.

trial registrationInternational Standard Randomized Controlled Trials Number (ISRCTN) registry ID ISRCTN57028065. Registration was accepted on 15 July 2021.

Indexed as

Deglutition DisordersHead and Neck NeoplasmsDeglutitionHumansMulticenter Studies as TopicQuality of LifeRandomized Controlled Trials as TopicSurvivorsTreatment OutcomeChemoradiotherapyChin Tuck against Resistance CTAR)DysphagiaExpiratory Muscle Strength Training (EMST)Head and neck cancerHigh-definition transcranial direct current stimulation (HD-tDCS)McNeill Dysphagia Therapy Program (MDTP)Non-invasive brain stimulationSwallowing exercisesTongue strengthening exercises

Identifiers

PMID36273210
PMCPMC9587548
OpenAlexW4307135320

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.