ArticleNature communications2022
Layer-specific, retinotopically-diffuse modulation in human visual cortex in response to viewing emotionally expressive faces.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 23 citations in OpenAlex.
- Distinct Representations of Irrelevant Emotional Information in the Visual Network Are Associated With Psychopathology in Youth.Biological psychiatry global open science · 2026Article
- Fusiform face area development correlates with development in higher-order social brain regions.Developmental cognitive neuroscience · 2026Article
- Study protocol for the Champaign-Urbana population study.Frontiers in neuroimaging · 2026Article
- Neural network dynamics associated with facial and subjective emotional responses.Communications biology · 2025Article
- Cross-spatial scale processing of hierarchical auditory sequences in human brains revealed using 7 T magnetic resonance imaging.Nature communications · 2025Article
- Using novel neural measures to explore the development of infant attention bias to threat.Developmental psychology · 2025Article
- Charting Decodability of Dynamic Facial Expressions in Young and Old Adults: Similarities and Differences.Experimental neurobiology · 2025Article
- The brain computes dynamic facial movements for emotion categorization using a third pathway.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Temporal Lobectomy Evidence for the Role of the Amygdala in Early Emotional Face and Body Processing.eNeuro · 2025Article
- Understanding human amygdala function with artificial neural networks.bioRxiv : the preprint server for biology · 2024Article
- Beyond faces: the contribution of the amygdala to visual processing in the macaque brain.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Emotion and anxiety interact to bias spatial attention.Emotion (Washington, D.C.) · 2024Article
- A comparative analysis of the sensitivity and BOLD contamination of the VASO response at 3 Tesla: ME-DEPICTING vs. ME-EPI readouts.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Widespread, perception-related information in the human brain scales with levels of consciousness.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Nonlocal contrast calculated by the second order visual mechanisms and its significance in identifying facial emotions.F1000Research · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 2 countries.
Funding
Abstract
Viewing faces that are perceived as emotionally expressive evokes enhanced neural responses in multiple brain regions, a phenomenon thought to depend critically on the amygdala. This emotion-related modulation is evident even in primary visual cortex (V1), providing a potential neural substrate by which emotionally salient stimuli can affect perception. How does emotional valence information, computed in the amygdala, reach V1? Here we use high-resolution functional MRI to investigate the layer profile and retinotopic distribution of neural activity specific to emotional facial expressions. Across three experiments, human participants viewed centrally presented face stimuli varying in emotional expression and performed a gender judgment task. We found that facial valence sensitivity was evident only in superficial cortical layers and was not restricted to the retinotopic location of the stimuli, consistent with diffuse feedback-like projections from the amygdala. Together, our results provide a feedback mechanism by which the amygdala directly modulates activity at the earliest stage of visual processing.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.