Evidence map›Paper›PMID 36273151›Full record

ArticleTrials2022

Personalized Disease Prevention (PDP): study protocol for a cluster-randomized clinical trial.

Glen B Taksler, Phuc Le, Bo Hu, Jay Alberts, Allen J Flynn, Michael B Rothberg

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05463887 (Personalized Disease Prevention), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 80% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05463887 nacompletednot on this map

Personalized Disease Prevention (PDP): A Randomized Clinical Trial

TypeinterventionalSponsorGlen TakslerRan2022 to 2026Enrolled721ConditionsPrimary Prevention, Healthy Aging, Quality of Life, Decision Support TechniquesArmsIndividualized preventive care recommendations (decision tool)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 0 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Glen B TakslerCleveland Clinic Community Care, Cleveland Clinic, 9500 Euclid Ave., G10, Cleveland, OH, USA. taksleg@ccf.org.ORCID http://orcid.org/0000-0002-7566-7104
Phuc LeCleveland Clinic Community Care, Cleveland Clinic, 9500 Euclid Ave., G10, Cleveland, OH, USA.
Bo HuDepartment of Quantitative Health Sciences, Cleveland Clinic, Cleveland, OH, USA.
Jay AlbertsDepartment of Biomedical Engineering, Cleveland Clinic, Cleveland, OH, USA.
Allen J FlynnSchool of Information and Department of Learning Health Sciences, University of Michigan, Ann Arbor, MI, USA.
Michael B RothbergCleveland Clinic Community Care, Cleveland Clinic, 9500 Euclid Ave., G10, Cleveland, OH, USA.
Cleveland Clinic · USUniversity of Michigan · US

Funding

Testing the Effectiveness of Individualized Disease Prevention for Middle-Aged AdultsR01AG059979 · NIA · CLEVELAND CLINIC LERNER COM-CWRU · PI TAKSLER, GLEN · 2019 to 2023
$3.4M
NIA NIH HHS R01 AG059979NIA NIH HHS R01AG059979NIA NIH HHS R01AG059979-S1
6 · The paper itself

Abstract

backgroundThe US Preventive Services Task Force recommends 25 primary preventive services for middle-aged adults, but it can be difficult to do them all.

methodsThe Personalized Disease Prevention (PDP) cluster-randomized clinical trial will evaluate whether patients and their providers benefit from an evidence-based decision tool to prioritize preventive services based on their potential to improve quality-adjusted life expectancy. The decision tool will be individualized for patient risk factors and available in the electronic health record. This Phase III trial seeks to enroll 60 primary care providers (clusters) and 600 patients aged 40-75 years. Half of providers will be assigned to an intervention to utilize the decision tool with approximately 10 patients each, and half will be assigned to usual care. Mixed-methods follow-up will include collection of preventive care utilization from electronic health records, patient and physician surveys, and qualitative interviews. We hypothesize that quality-adjusted life expectancy will increase by more in patients who receive the intervention, as compared with controls. DISCUSSION: PDP will test a novel, holistic approach to help patients and providers prioritize the delivery of preventive services, based on patient risk factors in the electronic health record.

trial registrationClinicalTrials.gov NCT05463887. Registered on July 19, 2022.

Indexed as

Electronic Health RecordsPreventive Health ServicesAdultAgedClinical Trials, Phase III as TopicHumansMiddle AgedRandomized Controlled Trials as TopicRisk FactorsSurveys and QuestionnairesDisease prevention, PrimaryMedicine, PreventivePatient-specific modelingPrecision medicinePrevention, PrimaryPreventive carePreventive Health Services

Identifiers

PMID36273151
PMCPMC9587586
OpenAlexW4307135246

What OpenQuestion holds

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LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.