ArticleJournal of ovarian research2022
The presence of ovarian endometrioma adversely affect ovarian reserve and response to stimulation but not oocyte quality or IVF/ICSI outcomes: a retrospective cohort study.
Article in Journal of ovarian research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 22 citations in OpenAlex.
- Oocyte quality in endometriosis-associated infertility: a narrative analysis of mechanisms and therapeutic options.Molecular biology reports · 2026Review
- The paradoxical association between endometrioma size and serum anti-Müllerian hormone levels in infertile women.Scientific reports · 2026Article
- Does endometrioma diameter impact serum anti-Müllerian hormone levels? A systematic review and meta-analysis.Human reproduction open · 2026Article
- Impact of endometrioma on iron levels and oxidative stress in the follicular fluid in women with endometriosis: a cross-sectional study.Scientific reports · 2025Article
- Should patients undergo endometrioma surgery before IVF/ICSI? a retrospective study with propensity score matching.Reproductive health · 2025Article
- Ovarian endometriosis negatively impacts pregnancy outcomes in young infertile women undergoing IVF/ICSI treatment.European journal of medical research · 2025Article
- Endometriosis does not impact aneuploidy rates of products of conception in IVF population.Scientific reports · 2025Article
- The influence of ovarian cyst type and size on ovarian reserve markers: implications for fertility counseling and preservation strategy.Frontiers in endocrinology · 2025Article
- Comparison of success rates in early stages of in vitro fertilization (IVF) in women with and without endometriosis.Narra J · 2024Article
- Oocyte cryopreservation for women with endometriosis: Justification, indications, and reproductive outcomes.Clinical and experimental reproductive medicine · 2024Article
- The impact of vitamin D treatment on pregnancy rate among endometriosis patients: a systematic review and meta-analysis.Annals of medicine and surgery (2012) · 2024Review
- Association between follicular fluid bacteria with inflammatory markers of the complete blood count and the outcomes of assisted reproductive technology in women with endometriosis: A case-control study.Health science reports · 2024Article
- Endometriosis and IVF treatment outcomes: unpacking the process.Reproductive biology and endocrinology : RB&E · 2023Review
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe possible impact of ovarian endometriomas (OMAs) on in vitro fertilization (IVF) outcomes remains controversial. Therefore, this study aimed to assess the impact of OMAs on IVF cycle parameters, including ovarian reserve and response to stimulation, embryo quality and pregnancy outcomes.
methodsThis retrospective cohort study included 2067 patients undergoing their first IVF/ICSI cycles between January 2018 and December 2020. The study group included 154 infertile women who had OMAs. The control group consisted of 1913 women without endometriosis, and finally 305 women were matched according to maternal age, body mass index (BMI), and infertility duration by propensity score matching (PSM). Cumulative live birth rate (CLBR) was set as the primary outcome measure. Logistic regression analysis was conducted on the basis of clinical covariates assessed for their association with CLBRs. Subgroup analyses were performed to evaluate the effect of ovarian surgery, cyst size and laterality on CLBRs.
resultsWomen with OMAs had significantly lower ovarian reserve markers (AMH and AFC), number of follicles, oocytes, embryos, and top-quality embryos than women in the control group (p < 0.05). However, the CLBRs were comparable between the two groups (55.64% versus 54.34%, p = 0.806), regardless of previous history of ovarian surgery. Multivariate analysis revealed association between age (OR = 0.861; 95% CI [0.806-0.921]; p = 0.000), top-quality embryos (OR = 1.829; 95% CI [1.526-2.193]; p = 0.000) and the CLBRs. A negative correlation between OMA size and AFC levels in patients with unoperated OMAs was detected (r = -0.264, p = 0.007). Meanwhile, significant decrease in ovarian reserve with lower AFC, fewer oocytes, embryos and top-quality embryos were observed in patients with OMAs size ≥ 6 cm (p < 0.05). Moreover, ovaries with OMAs had a significantly lower AFC (P = 0.006) but similar number of oocytes when compared with contralateral ovaries without OMAs.
conclusionInfertile women with OMAs were implicated in considerable decreases in ovarian reserve and response to stimulation, but no apparent adverse effects on oocyte quality or clinical outcomes. OMAs surgery and OMAs size may adversely affect ovarian reserve, but not CLBR.
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