ArticleRadiation oncology (London, England)2022
Comparing biological effectiveness guided plan optimization strategies for cranial proton therapy: potential and challenges.
Article in Radiation oncology (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed.
- Dynamic Proton arc therapy for paediatric parameningeal rhabdomyosarcoma.Journal of applied clinical medical physics · 2026Article
- Quantitative analysis of robustness-based versus LET-based optimization in intensity-modulated proton therapy for pediatric brain tumors.Journal of applied clinical medical physics · 2026Article
- Commissioning of a Monte Carlo-based scanning proton beam for breast cancer: Incorporating LETd calculations and variable RBE models.Journal of applied clinical medical physics · 2026Article
- Proof-of-principle of 3D-printed track-end detectors for dosimetry in proton therapy.Medical physics · 2025Article
- 'Dirty dose'-based proton variable RBE models - performance assessment on in vitro data.Medical physics · 2025Article
- Recommendations for reporting and evaluating proton therapy beyond dose and constant relative biological effectiveness.Physics and imaging in radiation oncology · 2025Article
- Beyond a constant proton relative biological effectiveness: A survey of clinical and research perspectives among proton institutions in Europe and the United States.Journal of applied clinical medical physics · 2025Article
- Enabling clinical use of linear energy transfer in proton therapy for head and neck cancer - A review of implications for treatment planning and adverse events study.Visualized cancer medicine · 2025Article
- Review
- Incorporating variable RBE in IMPT optimization for ependymoma.Journal of applied clinical medical physics · 2024Article
- Article
- Review
- Novel unconventional radiotherapy techniques: Current status and future perspectives - Report from the 2nd international radiation oncology online seminar.Clinical and translational radiation oncology · 2023Article
- Superiorization of projection algorithms for linearly constrained inverse radiotherapy treatment planning.Frontiers in oncology · 2023Article
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo introduce and compare multiple biological effectiveness guided (BG) proton plan optimization strategies minimizing variable relative biological effectiveness (RBE) induced dose burden in organs at risk (OAR) while maintaining plan quality with a constant RBE.
methodsDose-optimized (DOSEopt) proton pencil beam scanning reference treatment plans were generated for ten cranial patients with prescription doses ≥ 54 Gy(RBE) and ≥ 1 OAR close to the clinical target volume (CTV). For each patient, four additional BG plans were created. BG objectives minimized either proton track-ends, dose-averaged linear energy transfer (LET
resultsAll plans were clinically acceptable. DOSEopt and BG optimized plans were comparable in target volume coverage, homogeneity and conformity. For recalculated D
conclusionsAll BG strategies reduced variable RBE-induced NTCPs to OARs. Reducing LET
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