Evidence map›Paper›PMID 36273086›Full record

ArticleBritish journal of cancer2022

Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016.

Jingru Yu, Alexander Ploner, Margaret Sällberg Chen, Ji Zhang, Gunilla Sandborgh-Englund, Weimin Ye

Open access · hybridAbstract read
In one paragraph

Article in British journal of cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.7field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 18 citations in OpenAlex.

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  9. Review
  10. Pancreatic Cancer: A Review of Risk Factors.Life (Basel, Switzerland) · 2024
    Review
  11. Article
  12. Review
  13. Review
  14. Review
  15. aMMP-8 POCT for Periodontal Disease: An Indicator of Poor Oral Health.Cancer control : journal of the Moffitt Cancer Center
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Jingru YuDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden. jingru.yu@ki.se.ORCID http://orcid.org/0000-0002-4157-4647
Alexander PlonerDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.ORCID http://orcid.org/0000-0002-5042-8326
Margaret Sällberg ChenDepartment of Dental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
Ji ZhangDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden.
Gunilla Sandborgh-EnglundDepartment of Dental Medicine, Karolinska Institutet, 171 77, Stockholm, Sweden.
Weimin YeDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, 171 77, Stockholm, Sweden. weimin.ye@ki.se.ORCID http://orcid.org/0000-0002-6859-4648
Karolinska Institutet · SEFujian Medical University · CN

Funding

Cancerfonden (Swedish Cancer Society) 2019-0264
6 · The paper itself

Abstract

backgroundPrevious studies have reported inconsistent results regarding the association between poor dental health and pancreatic cancer risk. This study aimed to assess this association using a well-functioning nationwide dental health registry in Sweden.

methodsInformation of exposures (dental caries, root canal infection, mild inflammation, and periodontitis; the number of teeth) was ascertained from the Swedish Dental Health Register, and occurrence of pancreatic cancer was identified from both cancer and cause of death registries. Hazard ratios (HRs) were estimated using Cox models.

resultsDuring a median of 7.2 years of follow-up, 10,081 pancreatic cancers were identified among 5,889,441 individuals. Compared with the healthy status, a higher risk of pancreatic cancer was observed in individuals with root canal infection, mild inflammation, and periodontitis in the <50 age group (P for trend <0.001). In the 50-70 age group, only the subgroup with periodontitis had an excess risk (multivariable-adjusted HR = 1.20, 95% confidence interval [CI] 1.11-1.29). No positive association with statistical significance was observed in the 70+ age group. Individuals with fewer teeth tended to have a higher risk in all age groups.

conclusionsOur results confirmed the association between poor dental health and pancreatic cancer risk, which warrants further studies on underlying mechanisms.

Indexed as

Dental CariesPancreatic NeoplasmsCohort StudiesHumansSweden

Identifiers

PMID36273086
PMCPMC9726876
OpenAlexW4307114137

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.