Evidence map›Paper›PMID 36273039›Full record

ArticleEye (London, England)2023

Clinical, biological, and ophthalmological characteristics differentiating arteritic from non-arteritic anterior ischaemic optic neuropathy.

Simon Parreau, Alexandre Dentel, Rania Mhenni, Stéphanie Dumonteil, Alexis Régent, Guillaume Gondran, Dominique Monnet, Antoine P Brézin, Kim-Heang Ly, Éric Liozon and 2 more

Open access · greenAbstract readComparative StudyMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Eye (London, England), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 3 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Simon ParreauDepartment of Internal Medicine, Paris Descartes University, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Paris, France. simon.parreau@hotmail.com.ORCID 0000-0002-1790-2962
Alexandre DentelDepartment of Ophthalmology, Fondation Adolphe-de-Rothschild hospital, Paris, France.
Rania MhenniUniversité de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France.
Stéphanie DumonteilDepartment of Internal Medicine, Hôpital Dupuytren, Limoges, France.
Alexis RégentDepartment of Internal Medicine, Paris Descartes University, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Paris, France.ORCID 0000-0002-8136-2454
Guillaume GondranDepartment of Internal Medicine, Hôpital Dupuytren, Limoges, France.
Dominique MonnetUniversité de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France.
Antoine P BrézinUniversité de Paris, Department of Ophthalmology, Hôpital Cochin, Paris, France.ORCID 0000-0001-8461-3119
Kim-Heang LyDepartment of Internal Medicine, Hôpital Dupuytren, Limoges, France.
Éric LiozonDepartment of Internal Medicine, Hôpital Dupuytren, Limoges, France.
Thomas SenéDepartment of Internal Medicine, Fondation Adolphe-de-Rothschild hospital, Paris, France.
Benjamin TerrierDepartment of Internal Medicine, Paris Descartes University, Referral Center for Rare Autoimmune and Systemic Diseases, Hôpital Cochin, Paris, France.
Hôpital Dupuytren · FRDélégation Paris 5 · FRUniversité Paris Cité · FRFondation Ophtalmologique Adolphe de Rothschild · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimsTo identify characteristics that can distinguish AAION from NAAION in emergency practice.

methodsThis is a multicentre retrospective case-control study. Ninety-four patients with AAION were compared to ninety-four consecutive patients with NAAION. We compared the clinical, biological, and ophthalmological characteristics at baseline of patients with AAION and those with NAAION.

resultsPatients with AAION were older and more likely to have arterial hypertension. Cephalic symptoms and acute-phase reactants were more frequent in AAION. Profound vision loss and bilateral involvement were more frequent in AAION at baseline. Central retinal and cilioretinal artery occlusions was only observed in AAION, and delayed choroidal perfusion was more frequently observed in AAION than in NAAION. Using logistic regression, an age >70 years (OR = 3.4, IC95% = 0.8-16.1, p = 0.105), absence of splinter haemorrhage (OR = 4.9, IC95% = 1.4-20.5, p = 0.019), delayed choroidal perfusion (OR = 7.2, IC95% = 2.0-28.0, p = 0.003), CRP > 7 mg/L (OR = 43.6, IC95% = 11.6-229.1, p < 0.001) and platelets >400 × G/L (OR = 27.5, IC95% = 4.6-270.9, p = 0.001) were independently associated with a diagnosis of AAION. An easy-to-use score based on these variables accurately distinguished AAION from NAAION with a sensitivity of 93.3% and specificity of 92.4%.

conclusionIn patients presenting with AION, a set of ophthalmological and laboratory criteria can efficiently discriminate patients with AAION and NAAION and can identify which patients would benefit from high-dose glucocorticoids. External validation of our results is required.

Indexed as

Giant Cell ArteritisOptic Neuropathy, IschemicRetinal Artery OcclusionAgedAged, 80 and overCase-Control StudiesFemaleHumansMaleRetrospective Studies

Identifiers

PMID36273039
PMCPMC10333225
OpenAlexW4307114942

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.