ArticleNature communications2022
Ectopic expression of sericin enables efficient production of ancient silk with structural changes in silkworm.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 33 citations in OpenAlex.
- Targeting the circadian negative regulatorMaterials today. Bio · 2026Article
- Silk sericin and its biomedical applications: extraction methods, genetic insights (Ser1-Ser6), and developments of multifunctional biomaterials for tissue regeneration.Frontiers in bioengineering and biotechnology · 2026Review
- Article
- Robust and Reproducible Monoclonal Antibody Production Using a Transgenic Silkworm System.International journal of molecular sciences · 2025Article
- Regionalization of gene expression and cell types in the silk gland of the pantry mothbioRxiv : the preprint server for biology · 2025Article
- Comparative Physiological, Proteomic, and Metabolomic Insights into a Promising Low-Pruning Mulberry Cultivar for Silkworm Rearing.International journal of molecular sciences · 2024Article
- Natural Silkworm Cocoon-Derived Separator with Na-Ion De-Solvated Function for Sodium Metal Batteries.Molecules (Basel, Switzerland) · 2024Article
- Natural Deep Eutectic Solvent-Assisted Construction of Silk Nanofibrils/Boron Nitride Nanosheets Membranes with Enhanced Heat-Dissipating Efficiency.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Bridging Nature and Engineering: Protein-Derived Materials for Bio-Inspired Applications.Biomimetics (Basel, Switzerland) · 2024Review
- TALEN-mediated homologous-recombination-based fibroin light chain in-fusion expression system inFrontiers in bioengineering and biotechnology · 2024Article
- Mechanism of hyperproteinemia-induced damage to female reproduction in a genetic silkworm model.iScience · 2023Article
- Sericin from Fibroin-Deficient Silkworms Served as a Promising Resource for Biomedicine.Polymers · 2023Review
- Dynamic Changes and Characterization of the Metal Ions in the Silk Glands and Silk Fibers of Silkworm.International journal of molecular sciences · 2023Article
- SericinInsects · 2023Article
- Integrative analysis of microbiota and metabolomics in chromium-exposed silkworm (Frontiers in microbiology · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Bombyx mori silk is a super-long natural protein fiber with a unique structure and excellent performance. Innovative silk structures with high performance are in great demand, thus resulting in an industrial bottleneck. Herein, the outer layer sericin SER3 is ectopically expressed in the posterior silk gland (PSG) in silkworms via a piggyBac-mediated transgenic approach, then secreted into the inner fibroin layer, thus generating a fiber with sericin microsomes dispersed in fibroin fibrils. The water-soluble SER3 protein secreted by PSG causes P25's detachment from the fibroin unit of the Fib-H/Fib-L/P25 polymer, and accumulation between the fibroin layer and the sericin layer. Consequently, the water solubility and stability of the fibroin-colloid in the silk glandular cavity, and the crystallinity increase, and the mechanical properties of cocoon fibers, moisture absorption and moisture liberation of the silk also improve. Meanwhile, the mutant overcomes the problems of low survival and abnormal silk gland development, thus enabling higher production efficiency of cocoon silk. In summary, we describe a silk gland transgenic target protein selection strategy to alter the silk fiber structure and to innovate its properties. This work provides an efficient and green method to produce silk fibers with new functions.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.