ArticleScientific reports2022
The moderating effect of prefrontal response to sleep-related stimuli on the association between depression and sleep disturbance in insomnia disorder.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 9 citations in OpenAlex.
- The Sleep Symptoms Are Directly Associated With Suicide Risk in Adolescents and Youth Patients With Depression.Depression and anxiety · 2026Article
- Prefrontal cortex hypoactivation in response to sleep-related pictures in shift workers.Brain structure & function · 2025Article
- State-specific thalamic dysregulation in chronic insomnia revealed by dynamic edge-centric functional connectivity.Scientific reports · 2025Article
- Reduced prefrontal activation during cognitive control under emotional interference in chronic insomnia disorder.Journal of sleep research · 2025Article
- Research on the effect of TMS on insomnia patients: EEG changes and prognostic modeling.Frontiers in neuroscience · 2025Article
- Alterations of sleep deprivation on brain function: A coordinate-based resting-state functional magnetic resonance imaging meta-analysis.World journal of psychiatry · 2024Article
- Bidirectional mechanism of comorbidity of depression and insomnia based on synaptic plasticity.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2023Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We investigated differences in brain activity in response to sleep-related pictures between chronic insomnia disorder (CID) patients and good sleepers (GS), and examined whether brain activity moderated the relationship between depressive symptoms and sleep disturbance in CID patients and GS. This study included 43 patients diagnosed with CID, based on the International Classification of Sleep Disorders-3, and 42 GS. The participants kept a sleep diary, underwent nocturnal polysomnography to measure sleep parameters, and completed self-report questionnaires to assess sleep and psychiatric symptoms. They underwent functional magnetic resonance imaging (fMRI) to examine differences in brain activity in response to sleep-related pictures compared to neutral pictures. A moderated moderation analysis was performed to investigate the moderating role of brain responses to sleep-related pictures in the association between depressive symptoms and sleep disturbance. Compared to GS, the brain responses to sleep-related stimuli were significantly lower in CID patients in the right lateral prefrontal cortex (LPFC) and dorsomedial prefrontal cortex (DMPFC). More severe depressive symptoms were significantly associated with longer sleep latency only when LPFC activity was low in CID patients, but not in GS. LPFC hypoactivity in response to sleep-related stimuli in CID patients could moderate the relationship between depression and sleep disturbance.
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