Evidence map›Paper›PMID 36272883›Full record

ReviewTrends in cell biology2023

Multifaceted mitochondrial quality control in brown adipose tissue.

Katia Aquilano, Beiyan Zhou, Jonathan R Brestoff, Daniele Lettieri-Barbato

Abstract readReview
In one paragraph

Review in Trends in cell biology, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
  6. SEL1L-HRD1 ERAD-autophagy interplay maintains mitochondrial homeostasis in brown adipocytes.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  7. Article
  8. Thermogenesis is limited by cellular competence.Frontiers in cell and developmental biology · 2026
    Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Review
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Katia AquilanoDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy. Electronic address: katia.aquilano@uniroma2.it.
Beiyan ZhouDepartment of Immunology, School of Medicine, University of Connecticut, Farmington, CT 06030, USA; Institute for Systems Genomics, University of Connecticut, Farmington, CT 06030, USA.
Jonathan R BrestoffDepartment of Pathology and Immunology, Washington University School of Medicine, Saint Louis, MO 63110, USA.
Daniele Lettieri-BarbatoDepartment of Biology, University of Rome Tor Vergata, 00133 Rome, Italy; IRCCS, Fondazione Santa Lucia, 00179 Rome, Italy. Electronic address: daniele.lettieri.barbato@uniroma2.it.

Funding

MiR-150 regulated adiose tissue B cells in obesityR01DK121805 · NIDDK · UNIVERSITY OF CONNECTICUT SCH OF MED/DNT · PI VELLA, ANTHONY T, ZHOU, BEIYAN · 2020 to 2024
$2.0M
Regulation of innate immune cell responses through cell-to-cell transfer of mitochondriaDP5OD028125 · OD · WASHINGTON UNIVERSITY · PI BRESTOFF, JONATHAN R · 2019 to 2023
$2.0M
NIDDK NIH HHS R01 DK121805NIH HHS DP5 OD028125
6 · The paper itself

Abstract

Brown adipose tissue (BAT) controls mammalian core body temperature by non-shivering thermogenesis. BAT is extraordinarily rich in mitochondria, which have the peculiarity of generating heat by uncoupled respiration. Since the mitochondrial activity of BAT is subject to cycles of activation and deactivation in response to environmental temperature changes, an integrated mitochondrial quality control (MQC) system is of fundamental importance to ensure BAT physiology. Here, we provide an overview of the conventional and alternative mechanisms through which thermogenic adipocytes selectively remove damaged parts of mitochondria and how macrophages participate in the MQC system by removing extracellular mitochondrial waste to maintain the thermogenic function of BAT.

Indexed as

Adipose Tissue, BrownMitochondriaAdipocytesAnimalsHumansMammalsadipocytesextracellular vesiclesimmune cellsmetabolismmitochondrial transferthermogenesis

Identifiers

PMID36272883
PMCPMC11657393

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.