Evidence map›Paper›PMID 36272761›Full record

ArticleAmerican journal of preventive medicine2022

Trends in U.S. Depression Prevalence From 2015 to 2020: The Widening Treatment Gap.

Renee D Goodwin, Lisa C Dierker, Melody Wu, Sandro Galea, Christina W Hoven, Andrea H Weinberger

Registry-linked trialOpen access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of preventive medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06752759 (Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting), which is not on this map. Cited by 274 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
274citing papers in PubMed, 12 pooled it
88.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06752759 phase3recruitingnot on this mapstarted 2024, after this paper: background citation

Nebulized Ketamine for the Treatment of Major Depressive Disorder in an Inpatient Setting: A Midazolam-controlled Randomized Controlled Trial

TypeinterventionalSponsorTheresa Jacob, PhD, MPHRan2024 to 2027Enrolled40ConditionsSevere Depression, Moderate Depression, Ketamine, MidazolamArmsnebulized ketamine, nebulized midazolam
3 · Its place in the literature

Who cites it

274 citing papers in PubMed, 12 syntheses or guidelines pooled it, 503 citations in OpenAlex.

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214 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 1 country.

Renee D GoodwinDepartment of Epidemiology and Biostatistics, Graduate School of Public Health and Health Policy, City University of New York, New York, New York; Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York. Electronic address: rdg66@columbia.edu.
Lisa C DierkerPsychology Department, Wesleyan University, Middletown, Connecticut.
Melody WuDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York.
Sandro GaleaBoston University School of Public Health, Boston, Massachusetts.
Christina W HovenDepartment of Epidemiology, Mailman School of Public Health, Columbia University, New York, New York; New York State Psychiatric Institute, New York, New York; Department of Psychiatry, College of Physicians and Surgeons, Columbia University, New York, New York.
Andrea H WeinbergerFerkauf Graduate School of Psychology, Yeshiva University, Bronx, New York; Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, New York.
Albert Einstein College of Medicine · USBoston University · USCity University of New York · USColumbia University · USNew York Psychoanalytic Society and Institute · USWesleyan University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMajor depression is a common and potentially lethal condition. Early data suggest that the population-level burden of depression has been exacerbated by the COVID-19 pandemic. Prepandemic estimates of depression prevalence are required to quantify and comprehensively address the pandemic's impact on mental health in the U.S.

methodsData were drawn from the 2015-2020 National Survey on Drug Use and Health, a nationally representative study of U.S. individuals aged ≥12 years. The prevalence of past-year depression and help seeking for depression were estimated from 2015 to 2019, and time trends were tested with Poisson regression with robust SEs. Point estimates were calculated for 2020 and not included in statistical trend analyses because of differences in data collection procedures.

resultsIn 2020, 9.2% (SE=0.31) of Americans aged ≥12 years experienced a past-year major depressive episode. Depression was more common among young adults aged 18-25 years (17.2%, SE=0.78), followed closely by adolescents aged 12-17 years (16.9%, SE=0.84). Depression increased most rapidly among adolescents and young adults and increased among nearly all sex, racial/ethnic, income, and education groups. Depression prevalence did not change among adults aged ≥35 years, and the prevalence of help seeking remained consistently low across the study period.

conclusionsFrom 2015 to 2019, there were widespread increases in depression without commensurate increases in treatment, and in 2020, past 12‒month depression was prevalent among nearly 1 in 10 Americans and almost 1 in 5 adolescents and young adults. Decisive action involving a multipronged public health campaign that includes evidence-based prevention and intervention to address this ongoing mental health crisis is urgently needed.

Indexed as

COVID-19Major Depressive DisorderAdolescentAdultDepressionHumansPandemicsPrevalenceYoung Adult

Identifiers

PMID36272761
PMCPMC9483000
OpenAlexW4296360598

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.