Evidence map›Paper›PMID 36272727›Full record

ArticleWorld neurosurgery2023

Long-Term Clinical Outcomes of Patients with Colorectal Cancer with Metastatic Epidural Spinal Cord Compression Treated with Hybrid Therapy (Surgery Followed by Stereotactic Body Radiation Therapy).

Vikram B Chakravarthy, Ben Schachner, Anubhav Amin, Anne S Reiner, Yoshiya Yamada, Adam Schmitt, Daniel S Higginson, Ilya Laufer, Mark H Bilsky, Ori Barzilai

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PubMed Full text at PMC Publisher
In one paragraph

Article in World neurosurgery, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Vikram B ChakravarthyDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ben SchachnerDepartment of Neurosurgery, University of Miami Miller School of Medicine, Miami, Florida, USA.
Anubhav AminDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Department of Neurosurgery, University of Washington, Seattle, Washington, USA.
Anne S ReinerDepartment of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Yoshiya YamadaDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Adam SchmittDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Daniel S HigginsonDepartment of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York, USA.
Ilya LauferDepartment of Neurosurgery, New York University Grossman School of Medicine, New York, New York, USA.
Mark H BilskyDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA; Department of Neurosurgery, Weill Cornell Medical College, New York-Presbyterian Hospital, New York, New York, USA.
Ori BarzilaiDepartment of Neurosurgery, Memorial Sloan Kettering Cancer Center, New York, New York, USA. Electronic address: barzilao@mskcc.org.
Memorial Sloan Kettering Cancer Center · USNew York University · USUniversity of Miami · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Hongbiao Carl Lekaye · 1985 to 2026
$347.4M
NCI NIH HHS P30 CA008748
6 · The paper itself

Abstract

backgroundHybrid therapy, consisting of separation surgery followed by stereotactic body radiation therapy, has become the mainstay treatment for radioresistant spinal metastases. Histology-specific outcomes for hybrid therapy are scarce. In clinical practice, colorectal cancer (CRC) is particularly thought to have poor outcomes regarding spinal metastases. The goal of this study was to evaluate clinical outcomes for patients treated with hybrid therapy for spinal metastases from CRC.

methodsThis retrospective study was performed at a tertiary cancer center. Adult patients with CRC spinal metastasis who were treated with hybrid therapy for high-grade epidural spinal cord or nerve root compression from 2005 to 2020 were included. Outcome variables evaluated included patient demographics, overall survival and progression-free survival, surgical and radiation complications, and clinical-genomic correlations.

resultsInclusion criteria were met by 50 patients. Progression of disease occurred in 7 (14%) patients at the index level, requiring reoperation and/or reirradiation at a mean of 400 days after surgery. Postoperative complications occurred in 16% of patients, with 3 (6%) requiring intervention. APC exon 14 and 16 mutations were found in 15 of 17 patients tested and in all 3 of 7 local failures tested. Twenty patients (40%) underwent further radiation due to disease progression at other spinal levels.

conclusionsHybrid therapy in patients with CRC resulted in 86.7% local control at 2 years after surgery, with limited complications. APC mutations are commonly present in CRC patients with spine metastases and may suggest worse prognosis. Patients with CRC spinal metastases commonly progress outside the index treatment level.

Indexed as

Colorectal NeoplasmsRadiosurgerySpinal Cord CompressionSpinal NeoplasmsAdultHumansRetrospective StudiesTreatment OutcomeAdenomatous polyposis coli gene mutationColorectal cancerHybrid therapyMetastatic spinal cord compressionOverall survivalSpineSpine oncologySpine radiosurgery

Identifiers

PMID36272727
PMCPMC10414758
OpenAlexW4306778494

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.