ArticleBrain, behavior, and immunity2023
Mitochondrial redox environments predict sensorimotor brain-behavior dynamics in adults with HIV.
Article in Brain, behavior, and immunity, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 20 citations in OpenAlex.
- Digital language measures capture episodic memory disruptions in people with human immunodeficiency virus: A machine learning study.The Clinical neuropsychologist · 2026Article
- Parkinsonism in people with virally suppressed HIV.The lancet. HIV · 2026Review
- Elevated neurotransmitter levels in people with HIV are associated with attention function.Neurobiology of disease · 2026Article
- Oscillatory Dynamics Serving Verbal Working Memory Differ in People with HIV and Are Linked To Disease Duration.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Motor-Related Neural Dynamics are Modulated by Regular Cannabis Use Among People with HIV.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2025Article
- Cannabis- and HIV-related perturbations to the cortical gamma dynamics supporting inhibitory processing.Brain communications · 2025Article
- Healthy aging is associated with altered visual gamma band onset and offset responses.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- People with HIV exhibit spectrally distinct patterns of rhythmic cortical activity serving cognitive flexibility.Neurobiology of disease · 2024Article
- Interplay between preclinical indices of obesity and neural signatures of fluid intelligence in youth.Communications biology · 2024Article
- Time-resolved quantification of fine hand movements as a proxy for evaluating bradykinesia-induced motor dysfunction.Scientific reports · 2024Article
- Clinical markers of HIV predict redox-regulated neural and behavioral function in the sensorimotor system.Free radical biology & medicine · 2024Article
- Spontaneous cortical activity is altered in persons with HIV and related to domain-specific cognitive function.Brain communications · 2024Article
- Age-related alterations in the oscillatory dynamics serving verbal working memory processing.Aging · 2023Article
- Regular cannabis use alters the neural dynamics serving complex motor control.Human brain mapping · 2023Article
- Movement-related beta and gamma oscillations indicate parallels and disparities between Alzheimer's disease and HIV-associated neurocognitive disorder.Neurobiology of disease · 2023Article
- Altered functional connectivity and oscillatory dynamics in polysubstance and cannabis only users during visuospatial processing.Psychopharmacology · 2023Article
- Article
- Regular cannabis use modulates the impact of HIV on the neural dynamics serving cognitive control.Journal of psychopharmacology (Oxford, England) · 2022Article
Corrections and comments
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Authors and funding
13 authors at 3 institutions in 2 countries.
Funding
Abstract
Despite virologic suppression, people living with HIV (PLWH) remain at risk for developing cognitive impairment, with aberrations in motor control being a predominant symptom leading to functional dependencies in later life. While the neuroanatomical bases of motor dysfunction have recently been illuminated, the underlying molecular processes remain poorly understood. Herein, we evaluate the predictive capacity of the mitochondrial redox environment on sensorimotor brain-behavior dynamics in 40 virally-suppressed PLWH and 40 demographically-matched controls using structural equation modeling. We used state-of-the-art approaches, including Seahorse Analyzer of mitochondrial function, electron paramagnetic resonance spectroscopy to measure superoxide levels, antioxidant activity assays and dynamic magnetoencephalographic imaging to quantify sensorimotor oscillatory dynamics. We observed differential modulation of sensorimotor brain-behavior relationships by superoxide and hydrogen peroxide-sensitive features of the redox environment in PLWH, while only superoxide-sensitive features were related to optimal oscillatory response profiles and better motor performance in controls. Moreover, these divergent pathways may be attributable to immediate, separable mechanisms of action within the redox environment seen in PLWH, as evidenced by mediation analyses. These findings suggest that mitochondrial redox parameters are important modulators of healthy and pathological oscillations in motor systems and behavior, serving as potential targets for remedying HIV-related cognitive-motor dysfunction in the future.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.