Evidence map›Paper›PMID 36272463›Full record

ArticleBiochimica et biophysica acta. Bioenergetics2023

Metabolic clearance of oxaloacetate and mitochondrial complex II respiration: Divergent control in skeletal muscle and brown adipose tissue.

Liping Yu, Brian D Fink, Ritu Som, Adam J Rauckhorst, Eric B Taylor, William I Sivitz

Open access · hybridAbstract read
In one paragraph

Article in Biochimica et biophysica acta. Bioenergetics, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.4field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Sex dimorphism and substrate dependency of liver mitochondrial bioenergetics and HAmerican journal of physiology. Gastrointestinal and liver physiology · 2025
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Article
  11. Saline-Alkali Soil Property Improved by the Synergistic Effects ofInternational journal of molecular sciences · 2023
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Liping YuDepartment of Biochemistry and Molecular Biology, University of Iowa, Iowa City, IA 52242, USA; Carver College of Medicine NMR Core Facility, University of Iowa, Iowa City, IA 52242, USA.
Brian D FinkDepartment of Internal Medicine/Endocrinology and Metabolism, University of Iowa and the Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, USA.
Ritu SomDepartment of Internal Medicine/Endocrinology and Metabolism, University of Iowa and the Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, USA.
Adam J RauckhorstDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
Eric B TaylorDepartment of Molecular Physiology and Biophysics, University of Iowa, Iowa City, IA 52242, USA.
William I SivitzDepartment of Internal Medicine/Endocrinology and Metabolism, University of Iowa and the Iowa City Veterans Affairs Medical Center, Iowa City, IA 52242, USA. Electronic address: william-sivitz@uiowa.edu.
University of Iowa · US

Funding

Regulation of Hepatic Macronutrient Metabolism by Mitochondrial Citrate TransportR01DK104998 · NIDDK · UNIVERSITY OF IOWA · PI TAYLOR, ERIC B · 2015 to 2022
$3.2M
UCP1 and the regulation of mitochondrial respiration in brown adipose tissue by oxaloacetateR01DK123043 · NIDDK · UNIVERSITY OF IOWA · PI SIVITZ, WILLIAM IRVING · 2020 to 2023
$1.3M
BLRD VA I01 BX000285NIDDK NIH HHS R01 DK104998NIDDK NIH HHS R01 DK123043
6 · The paper itself

Abstract

At low inner mitochondrial membrane potential (ΔΨ) oxaloacetate (OAA) accumulates in the organelles concurrently with decreased complex II-energized respiration. This is consistent with ΔΨ-dependent OAA inhibition of succinate dehydrogenase. To assess the metabolic importance of this process, we tested the hypothesis that perturbing metabolic clearance of OAA in complex II-energized mitochondria would alter O

Indexed as

Oxaloacetic AcidSuccinate DehydrogenaseAdipose Tissue, BrownMuscle, SkeletalPyruvic AcidRespirationSuccinic AcidOxaloacetic AcidPyruvic AcidSuccinate DehydrogenaseSuccinic AcidBrown adipose tissueMitochondriaMitochondrial complex IIMuscleOxaloacetateSuccinate dehydrogenase

Identifiers

PMID36272463
PMCPMC10225247
OpenAlexW4306850900

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.