Evidence map›Paper›PMID 36272099›Full record

ArticleJournal of neurochemistry2023

Neurochemical correlates of synapse density in a Huntington's disease mouse model.

Nicole Zarate, Katherine Gundry, Dahyun Yu, Jordan Casby, Lynn E Eberly, Gülin Öz, Rocio Gomez-Pastor

Open access · hybridAbstract read
In one paragraph

Article in Journal of neurochemistry, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.4field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Silmitasertib, an FDA-designated orphan CK2 inhibitor, ameliorates neuropathology and motor dysfunction in a Huntington's disease mouse model.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Nicole ZarateDepartment of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4839-7783
Katherine GundryDepartment of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-3333-1709
Dahyun YuDepartment of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-3179-4080
Jordan CasbyDepartment of Pharmacology, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-5601-3906
Lynn E EberlyDepartment of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-4763-330X
Gülin ÖzDepartment of Radiology, Center for Magnetic Resonance Research, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0002-5769-183X
Rocio Gomez-PastorDepartment of Neuroscience, Medical School, University of Minnesota, Minneapolis, Minnesota, USA.ORCID 0000-0003-1136-5462
University of Minnesota Medical Center · USUniversity of Minnesota · US

Funding

TRD4 - Ultrahigh Field Engineering and SafetyP41EB027061 · NIBIB · UNIVERSITY OF MINNESOTA · PI Gregory John Metzger · 2019 to 2026
$11.7M
Institutional Center Cores for Advanced NeuroimagingP30NS076408 · NINDS · UNIVERSITY OF MINNESOTA · PI UGURBIL, KAMIL · 2012 to 2020
$4.2M
Molecular mechanisms of synaptic dysfunction and cognitive decline in Huntington's diseaseR01NS110694 · NINDS · UNIVERSITY OF MINNESOTA · PI Rocio Gomez-Pastor · 2020 to 2026
$3.1M
NIBIB NIH HHS P41 EB027061NINDS NIH HHS P30 NS076408NINDS NIH HHS R01 NS110694
6 · The paper itself

Abstract

Striatal medium spiny neurons are highly susceptible in Huntington's disease (HD), resulting in progressive synaptic perturbations that lead to neuronal dysfunction and death. Non-invasive imaging techniques, such as proton magnetic resonance spectroscopy (

Indexed as

Huntington DiseaseAnimalsCorpus StriatumDisease Models, AnimalMiceMice, TransgenicNeostriatumNeuronsSynapses1H-MRSCK2 alpha primeHuntington's diseaseneurochemicalssynapse densityzQ175

Identifiers

PMID36272099
PMCPMC9892354
OpenAlexW4307093833

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.