Evidence map›Paper›PMID 36272043›Full record

ArticleJournal of autism and developmental disorders2024

Could Sensory Differences Be a Sex-Indifferent Biomarker of Autism? Early Investigation Comparing Tactile Sensitivity Between Autistic Males and Females.

Magdalini Asaridou, Ericka L Wodka, Richard A E Edden, Stewart H Mostofsky, Nicolaas A J Puts, Jason L He

Open access · hybridAbstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.

  1. Pooled it
  2. Adaptive Functioning, Sensory Processing, and Behavioral Problems in Autistic Children: The Moderating Role of Gender.Autism research : official journal of the International Society for Autism Research · 2026
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  10. Forwarding the Science of Sensory Features in Autism and Related Conditions.Journal of autism and developmental disorders · 2024
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Magdalini AsaridouSocial, Genetic and Developmental Psychiatric Centre, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Ericka L WodkaCenter for Autism and Related Disorders, Kennedy Krieger Institute, Baltimore, MD, USA.
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Stewart H MostofskyDepartment of Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Nicolaas A J PutsDepartment of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK.
Jason L HeDepartment of Forensic and Neurodevelopmental Sciences, Sackler Institute for Translational Neurodevelopment, Institute of Psychiatry, Psychology, and Neuroscience, King's College London, London, UK. jason.he@kcl.ac.uk.ORCID http://orcid.org/0000-0003-2983-0166
Kennedy Krieger Institute · USKing's College London · GB

Funding

Sleep and Circadian Dysfunction, Brain and Neurobehavioral Development in AutismP50HD103538 · NICHD · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI S. Ali Fatemi, Bradley L Schlaggar · 2020 to 2026
$9.9M
Anomalous Motor Physiology In ADHDR01MH078160 · NIMH · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI MOSTOFSKY, STEWART H · 2006 to 2024
$5.8M
Somatosensory Inhibitory Dysfunction in Autism Spectrum Disorder.R01MH106564 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2016 to 2020
$2.5M
A Multimodal Investigation of Inhibitory Dysfunction in Autism Spectrum DisorderR00MH107719 · NIMH · JOHNS HOPKINS UNIVERSITY · PI PUTS, NICOLAAS · 2018 to 2019
$492k
Dysfunction of Sensory Inhibition in AutismR21MH098228 · NIMH · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2013 to 2014
$460k
Medical Research Council MR/N026063/1NICHD NIH HHS P50 HD103538NIMH NIH HHS R00 MH107719NIMH NIH HHS R01 MH078160NIMH NIH HHS R01 MH106564NIMH NIH HHS R21 MH098228
6 · The paper itself

Abstract

Sensory differences are highly prevalent in autistic individuals. However, few studies have compared their presentation between autistic males and autistic females. We used psychophysics to assess and compare tactile perceptual sensitivity between autistic and non-autistic boys and girls aged between 8 and 12 years of age. While there were sex-differences of amplitude discrimination, frequency discrimination and order judgement thresholds, these sex-differences were not autism-specific. Mean RTs and detection thresholds were elevated in autism but were comparable between the sexes. Tactile sensitivity measures that are elevated in autism but are otherwise comparable between autistic males and autistic females suggest the possibility that certain sensory features could be used as sex-indifferent markers of autism. Further investigation with larger and more representative samples should be conducted before any stronger conclusions are made.

Indexed as

Autism Spectrum DisorderAutistic DisorderChild Development Disorders, PervasiveBiomarkersChildFemaleHumansMaleSexual BehaviorBiomarkersAutismPsychophysicsSensorySex-differencesTactile

Identifiers

PMID36272043
PMCPMC10791919
OpenAlexW4307090514

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.