ReviewJournal of anesthesia2023
Analgesia nociception index and high frequency variability index: promising indicators of relative parasympathetic tone.
Review in Journal of anesthesia, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
29 citing papers in PubMed, 42 citations in OpenAlex.
- Trial
- Pain monitoring in intensive care: How does the nociception level index affect treatment and prognosis? A randomized, controlled, double-blind trial.Ulusal travma ve acil cerrahi dergisi = Turkish journal of trauma & emergency surgery : TJTES · 2024Trial
- Pre-induction nociception indices are associated with post-induction hypotension during general anesthesia in older patients: a prospective observational study.Journal of clinical monitoring and computing · 2026Observational
- Effects of remimazolam and propofol on parasympathetic activity during general anesthesia induction in patients with severe aortic stenosis: a randomized controlled trial utilizing high-frequency variability index.Journal of clinical monitoring and computing · 2026Article
- Effect of IoC2-guided analgesic titration on intraoperative opioid consumption in older patients undergoing laparoscopic colorectal surgery: a randomized controlled trial.Journal of anesthesia · 2026Article
- Depth of anesthesia monitoring: Current evidence, clinical impact, and future directions.The Journal of international medical research · 2026Review
- Dexmedetomidine attenuates nociceptive responses compared with propofol during intravenous sedation for dental surgery: a prospective observational study.Journal of dental anesthesia and pain medicine · 2026Article
- Changes in pulse wave transit time variability after interscalene brachial plexus block placement.Korean journal of anesthesiology · 2026Article
- Assessment of intraoperative high frequency variability index as a predictor of postoperative pain after open liver or pancreatic surgery under combined general and epidural anesthesia: a prospective observational study.Journal of clinical monitoring and computing · 2025Observational
- Application of the Analgesia Nociception Index and Visual Analog Scale to Assess Pain During Hysteroscopy Under Local Anesthesia.Journal of clinical medicine · 2025Article
- Effect of postoperative peripheral nerve blocks on the analgesia nociception index under propofol anesthesia: an observational study.Journal of clinical monitoring and computing · 2025Observational
- Multimodal sedation guided by processed electroencephalography and autonomic nervous system monitoring for spinal cord stimulator implantation: retrospective identification of anesthetic drug doses.Journal of anesthesia, analgesia and critical care · 2025Article
- Article
- Recording rates of high-frequency variability index monitoring and use of vasoactive medications in daily clinical practice: A prospective observational study.Indian journal of anaesthesia · 2025Article
- High frequency variability index in predicting postoperative pain in video/robotic-assisted thoracoscopic surgery under combined general anesthesia and peripheral nerve block: an observational study.Journal of clinical monitoring and computing · 2025Observational
- Analgesia Nociception Index Monitoring in Management of Perioperative Analgesia in Total Knee Arthroplasty Surgeries with Femoral Nerve Block.Medicina (Kaunas, Lithuania) · 2025Article
- Comparison of the effects of two regional anesthetic techniques on pain during high risk hip fracture surgery.American journal of translational research · 2025Article
- Limitations of high-frequency variability index in pain monitoring during pheochromocytoma resection.Indian journal of anaesthesia · 2024Article
- Exploring Heart Rate Variability Biofeedback as a Nonpharmacological Intervention for Enhancing Perioperative Care: A Narrative Review.Turkish journal of anaesthesiology and reanimation · 2024Article
- Interference with high-frequency variability index.Journal of anesthesia · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
At present, there is no objective and absolute measure of nociception, although various monitoring techniques have been developed. One such technique is the Analgesia Nociception Index (ANI), which is calculated from heart rate variability that reflects the relative parasympathetic tone. ANI is expressed on a non-unit scale of 0-100 (100 indicates maximal relative parasympathetic tone). Several studies indicated that ANI-guided anesthesia may help reduce intraoperative opioid use. The usefulness of ANI in the intensive care unit (ICU) and during surgery has also been reported. However, some limitations of ANI have also been reported; for example, ANI is affected by emotions and some drugs. In 2022, a high frequency variability index (HFVI), which was renamed from ANI and uses the same algorithm as ANI, was commercialized; therefore, ANI/HFVI are currently in the spotlight. Unlike ANI, HFVI can be displayed along with other biometric information on the Root
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.