ArticleApplied microbiology and biotechnology2022
Development of efficient 5-ketogluconate production system by Gluconobacter japonicus.
Article in Applied microbiology and biotechnology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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5 citing papers in PubMed, 7 citations in OpenAlex.
- De novo L-(+)-tartaric acid biosynthesis in multi-modular engineered yeasts.Nature communications · 2026Article
- From Glucose to Green Chemistry: Breakthrough in Microbial Production of Tartaric Semialdehyde.Microbial biotechnology · 2025Article
- Two NADPH-dependent 2-ketogluconate reductases involved in 2-ketogluconate assimilation inApplied and environmental microbiology · 2025Article
- Enhancing levan biosynthesis by destroying the strongly acidic environment caused by membrane-bound glucose dehydrogenase (mGDH) inSynthetic and systems biotechnology · 2025Article
- High-yield production of 5-keto-D-gluconic acid via regulated fermentation strategy ofHeliyon · 2024Article
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Authors and funding
5 authors at 2 institutions in 1 country.
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Abstract
5-Ketogluconate (5KGA) is a precursor for synthesizing tartrate, a valuable compound used in several industries. In a previous study, Gluconobacter japonicus NBRC 3271 mutant strain D2, which lacks two membranous gluconate 2-dehydrogenases, was shown to produce 5KGA but not 2-ketogluconate from a mixture of glucose and gluconate. In this study, we aimed to develop an efficient 5KGA production system using G. japonicus D2 as the parental strain. D2 produced 5KGA from glucose in a jar fermentor culture; however, 5KGA levels were reduced during the late phase of cultivation. To increase the potential of D2 for 5KGA production, the cytoplasmic metabolism related to the utilization of 5KGA and gluconate was modified; the gno and gntK genes encoding 5KGA reductase and gluconokinase, respectively, were deleted from D2, generating D4. Improved 5KGA production was observed in D4 compared to that in D2, but a significant amount of gluconate remained at the end of cultivation, leading to an unsatisfied yield of 0.83 mol (mol glucose)
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