Evidence map›Paper›PMID 36271909›Full record

ArticleActa paediatrica (Oslo, Norway : 1992)2023

Investigating genetic variants in microRNA regulators of Neurokinin-1 receptor in sudden infant death syndrome.

Zeeshan Shaukat, Roger W Byard, Robert Vink, Rashid Hussain, Michael G Ricos, Leanne M Dibbens

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Acta paediatrica (Oslo, Norway : 1992), 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 54% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Zeeshan ShaukatClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.ORCID 0000-0002-4507-7752
Roger W ByardForensic Science SA, School of Health Sciences, The University of Adelaide, Adelaide, South Australia, Australia.ORCID 0000-0002-0524-5942
Robert VinkClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Rashid HussainClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Michael G RicosClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
Leanne M DibbensClinical and Health Sciences, University of South Australia, Adelaide, South Australia, Australia.
University of South Australia · AUSA Health · AU

Funding

National Health and Medical Research Council 1104718National Health and Medical Research Council 1125523Rivers Gift Limited (ACNC registered Health Promotion Charity), University of South Australia
6 · The paper itself

Abstract

Sudden infant death syndrome (SIDS) occurs more often in male than in female infants, suggesting involvement of the X-chromosome. Histopathological studies have suggested that altered expression of the Neurokinin-1 receptor may also play a role in the pathogenesis of SIDS. It was hypothesised that genetic variants in three X-chromosome-encoded microRNA (miRNA/miR), known to down-regulate expression of the Neurokinin-1 receptor, may contribute to SIDS.

aimTo identify sequence variants in the miRNAs within a study cohort (27 cases of SIDS and 28 controls) and determine if there was a difference in the frequencies in male and female SIDS infants.

methodsGenomic DNA prepared from stored blood spots was amplified and sequenced to identify genetic variants in miR500A, miR500B and miR320D2.

resultsNo novel variants in the miRNAs were identified in our study cohort. We identified one known single-nucleotide polymorphism (SNP) in miR320D2: rs5907732 G/T, in both cases and controls. No significant difference in the SNP frequency was observed between male and female SIDS cases.

conclusionThis pilot study suggests that sequence variants in three miRNAs do not contribute to the reported higher prevalence of SIDS in male infants and do not contribute to the pathogenesis of SIDS in our cohort.

Indexed as

MicroRNAsSudden Infant DeathFemaleHumansInfantMalePilot ProjectsPolymorphism, Single NucleotideReceptors, Neurokinin-1MicroRNAsReceptors, Neurokinin-1forensicGenetic variationmicroRNAsequencingSIDSsudden infant death

Identifiers

PMID36271909
PMCPMC10952777
OpenAlexW4307092350

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.