Evidence map›Paper›PMID 36271899›Full record

ArticleNMR in biomedicine2023

Feasibility and implications of using subject-specific macromolecular spectra to model short echo time magnetic resonance spectroscopy data.

Helge J Zöllner, Christopher W Davies-Jenkins, Saipavitra Murali-Manohar, Tao Gong, Steve C N Hui, Yulu Song, Weibo Chen, Guangbin Wang, Richard A E Edden, Georg Oeltzschner

Abstract read
In one paragraph

Article in NMR in biomedicine, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
  2. A data-driven algorithm to determineMagnetic resonance in medicine · 2026
    Article
  3. Article
  4. Blood and neuronal extracellular vesicle mitochondrial disruptions in schizophrenia.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025
    Article
  5. Article
  6. Article
  7. Metabolite TNMR in biomedicine · 2024
    Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Brain glutathione and GABA+ levels in autistic children.Autism research : official journal of the International Society for Autism Research · 2024
    Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Helge J ZöllnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-7148-292X
Christopher W Davies-JenkinsRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-6015-762X
Saipavitra Murali-ManoharRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-4978-0736
Tao GongDepartments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0001-9689-0420
Steve C N HuiRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-1523-4040
Yulu SongRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Weibo ChenPhilips Healthcare, Shanghai, China.
Guangbin WangDepartments of Radiology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.ORCID 0000-0002-3099-7273
Richard A E EddenRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0002-0671-7374
Georg OeltzschnerRussell H. Morgan Department of Radiology and Radiological Science, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID 0000-0003-3083-9811

Funding

TRD 4: Platforms for multi-modal and multi-scale imaging dataP41EB031771 · NIBIB · HUGO W. MOSER RES INST KENNEDY KRIEGER · PI Hanzhang Lu, Peter CM Van Zijl · 2021 to 2026
$9.9M
Universal GABA-edited MRS at 3TR01EB016089 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI Richard Anthony Edward Edden · 2013 to 2026
$5.4M
Simultaneous Hadamard Editing of GABA and GlutathioneR01EB023963 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2017 to 2024
$3.8M
Towards a comprehensive neurometabolic profile in patients with mild cognitive impairment.R00AG062230 · NIA · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2021 to 2023
$735k
General Linear Modeling For Magnetic Resonance SpectroscopyR21EB033516 · NIBIB · JOHNS HOPKINS UNIVERSITY · PI OELTZSCHNER, GEORG · 2022 to 2024
$670k
Neurometabolic profile of mild cognitive impairment using multiplexed edited MRSR21AG060245 · NIA · JOHNS HOPKINS UNIVERSITY · PI EDDEN, RICHARD ANTHONY EDWARD · 2018 to 2019
$466k
NIA NIH HHS R00 AG062230NIA NIH HHS R21 AG060245NIBIB NIH HHS P41 EB031771NIBIB NIH HHS R01 EB016089NIBIB NIH HHS R01 EB023963NIBIB NIH HHS R21 EB033516
6 · The paper itself

Abstract

Expert consensus recommends linear-combination modeling (LCM) of

Indexed as

BrainCholineFeasibility StudiesHumansMacromolecular SubstancesMagnetic Resonance SpectroscopyReceptors, Antigen, T-CellSignal-To-Noise RatioCholineMacromolecular SubstancesReceptors, Antigen, T-Cellaging, linear-combination modeling, macromolecules, short-TE MRS

Identifiers

PMID36271899
PMCPMC9930668

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.