ArticleAnnals of neurology2022
Network Effects of Brain Lesions Causing Central Poststroke Pain.
Article in Annals of neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 27 citations in OpenAlex.
- A hematoma location-based nomogram for individualized prediction of thalamic pain after spontaneous thalamic hemorrhage.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Neuroimaging Correlates of Post-Stroke Pain After Ischemic Stroke: Secondary Analysis of the INSPiRE-TMS Trial.Human brain mapping · 2026Article
- Abnormal structural gray matter and structural covariance networks associated with biopsychosocial characteristics in children with multisite pain.The journal of headache and pain · 2025Article
- Prediction of etiology and prognosis based on hematoma location of spontaneous intracerebral hemorrhage: a multicenter diagnostic study.Neuroradiology · 2025Article
- Article
- Functional magnetic resonance imaging and diffuse tensor imaging diagnostic values in central post-stroke pain.Postepy psychiatrii neurologii · 2025Review
- Converging Evidence for Frontopolar Cortex as a Target for Neuromodulation in Addiction Treatment.The American journal of psychiatry · 2024Review
- Network targets for therapeutic brain stimulation: towards personalized therapy for pain.Frontiers in pain research (Lausanne, Switzerland) · 2023Article
- Neuromodulation approaches and applications in the management of post-stroke pain: a comprehensive review.Frontiers in neurologyReview
Corrections and comments
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Authors and funding
9 authors at 5 institutions in 5 countries.
Funding
Abstract
objectiveThis study was undertaken to test whether lesions causing central poststroke pain (CPSP) are associated with a specific connectivity profile, whether these connections are associated with metabolic changes, and whether this network aligns with neuromodulation targets for pain.
methodsTwo independent lesion datasets were utilized: (1) subcortical lesions from published case reports and (2) thalamic lesions with metabolic imaging using 18F- fluorodeoxyglucose positron emission tomography-computed tomography. Functional connectivity between each lesion location and the rest of the brain was assessed using a normative connectome (n = 1,000), and connections specific to CPSP were identified. Metabolic changes specific to CPSP were also identified and related to differences in lesion connectivity. Therapeutic relevance of the network was explored by testing for alignment with existing brain stimulation data and by prospectively targeting the network with repetitive transcranial magnetic stimulation (rTMS) in 7 patients with CPSP.
resultsLesion locations causing CPSP showed a specific pattern of brain connectivity that was consistent across two independent lesion datasets (spatial r = 0.82, p < 0.0001). Connectivity differences were correlated with postlesion metabolism (r = -0.48, p < 0.001). The topography of this lesion-based pain network aligned with variability in pain improvement across 12 prior neuromodulation targets and across 32 patients who received rTMS to primary motor cortex (p < 0.05). Prospectively targeting this network with rTMS improved CPSP in 6 of 7 patients.
interpretationLesions causing pain are connected to a specific brain network that shows metabolic abnormalities and promise as a neuromodulation target. ANN NEUROL 2022;92:834-845.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.