Evidence map›Paper›PMID 36271646›Full record

SynthesisTransplant infectious disease : an official journal of the Transplantation Society2022

The impact of preservation fluid culture on graft site arteritis: A systematic review and meta-analysis.

Matteo Rinaldi, Cecilia Bonazzetti, Milo Gatti, Natascia Caroccia, Giorgia Comai, Matteo Ravaioli, Maria Cristina Morelli, Pierluigi Viale, Maddalena Giannella

Open access · hybridAbstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in Transplant infectious disease : an official journal of the Transplantation Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 9 citations in OpenAlex.

  1. The impact of preservation fluid culture on graft site arteritis: A systematic review and meta-analysis.Transplant infectious disease : an official journal of the Transplantation Society · 2022
    Pooled it
  2. Article
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Matteo RinaldiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0002-3568-5973
Cecilia BonazzettiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Milo GattiDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Natascia CarocciaInfectious Diseases Unit, Department for Integrated Infectious Risk Management, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Bologna, Italy.
Giorgia ComaiNephrology, Dialysis and Renal Transplant Unit, IRCCS Azienda Ospedaliero Universitaria di Bologna, Alma Mater Studiorum, University of Bologna, Bologna, Italy.
Matteo RavaioliDepartment of Hepatobiliary and Transplant Surgery, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Alma Mater Studiorum, University Hospital, Bologna, Italy.
Maria Cristina MorelliInternal Medicine Unit for the Treatment of Severe Organ Failure, IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola, Bologna, Italy.
Pierluigi VialeDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.
Maddalena GiannellaDepartment of Medical and Surgical Sciences, Alma Mater Studiorum University of Bologna, Bologna, Italy.ORCID https://orcid.org/0000-0001-8273-7601
Azienda USL di Bologna · ITIRCCS Azienda Ospedliero-Universitaria di Bologna Policlinico di Sant'Orsola · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe role of culturing the graft preservation fluid (PF) is controversial and its impact on graft arteritis development remains unclear.

methodsSystematic literature search retrieving observational studies comparing solid organ transplant (SOT) recipients with culture-positive PF versus culture-negative PF. The quality of included studies was independently assessed according to the ROBINS-I tool for observational studies. Meta-analysis was performed using Mantel-Haenszel random-effect models. Graft site arteritis within 180 days from transplant was selected as the primary outcome.

resultsTwenty-one observational studies (N = 2208 positive PF vs. 4458 negative) were included. Among positive PF, 857 (38.8%) were classified as high-risk group pathogens and 1351 (61.2%) as low-risk pathogens. Low-risk and negative PF showed similar odds ratios. A significant higher risk of graft arteritis was found in SOT recipients with a PF yielding a high-risk pathogen (odds ratio [OR] 18.43, 95% confidence interval [CI] 7.83-43.40) compared to low-risk and negative PF, with low heterogeneity (I

conclusionsOur results may support the performance of PF culturing and a preemptive diagnostic or therapeutic management upon isolation of high-risk pathogens. Further studies based on a reliable diagnosis of graft arteritis are needed.

Indexed as

ArteritisLiverBacteriaFungiHumansgraft arteritismycotic aneurismpreservation fluidsolid organ transplantation

Identifiers

PMID36271646
PMCPMC10078333
OpenAlexW4307091130

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.