Evidence map›Paper›PMID 36271419›Full record

ArticleCritical care (London, England)2022

Dehydration is associated with production of organic osmolytes and predicts physical long-term symptoms after COVID-19: a multicenter cohort study.

Michael Hultström, Miklos Lipcsey, Dave R Morrison, Tomoko Nakanishi, Guillaume Butler-Laporte, Yiheng Chen, Satoshi Yoshiji, Vincenzo Forgetta, Yossi Farjoun, Ewa Wallin and 7 more

2 registry-linked trialsOpen access · goldAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Critical care (London, England), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04316884 completednot on this map

Uppsala Intensive Care Study of Mechanisms for Organ Dysfunction in Covid-19

TypeobservationalSponsorUppsala UniversityRan2020 to 2025Enrolled380ConditionsCOVID-19, Organ Dysfunction Syndrome Sepsis, Organ Dysfunction Syndrome, Multiple, Septic Shock
NCT04474249 unknown statusnot on this map

Uppföljning av Patienter Som intensivvårdats för COVID-19

TypeobservationalSponsorUppsala UniversityRan2020 to 2022Enrolled300ConditionsCOVID19, ARDS, AKI, Circulatory Failure
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 7 institutions in 6 countries.

Michael HultströmAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, ANOPIVA, Ing70, 2Tr, 75185, Uppsala, Sweden. michael.hultstrom@mcb.uu.se.
Miklos LipcseyAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, ANOPIVA, Ing70, 2Tr, 75185, Uppsala, Sweden.
Dave R MorrisonDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Tomoko NakanishiLady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Guillaume Butler-LaporteDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Yiheng ChenLady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Satoshi YoshijiLady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Vincenzo ForgettaLady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Yossi FarjounLady Davis Institute of Medical Research, Jewish General Hospital, McGill University, Montreal, QC, Canada.
Ewa WallinAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, ANOPIVA, Ing70, 2Tr, 75185, Uppsala, Sweden.
Ing-Marie LarssonAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, ANOPIVA, Ing70, 2Tr, 75185, Uppsala, Sweden.
Anders LarssonClinical Chemistry, Department of Medical Sciences, Uppsala University, Uppsala, Sweden.
Adriana MartonProgram in Cardiovascular and Metabolic Disorders, Duke- NUS Medical School, Singapore, Singapore.
Jens Marc TitzeProgram in Cardiovascular and Metabolic Disorders, Duke- NUS Medical School, Singapore, Singapore.
Sandra NihlénAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, ANOPIVA, Ing70, 2Tr, 75185, Uppsala, Sweden.
J Brent RichardsDepartment of Epidemiology, Biostatistics and Occupational Health, McGill University, Montreal, QC, Canada.
Robert FrithiofAnaesthesiology and Intensive Care Medicine, Department of Surgical Sciences, Uppsala University, Akademiska Sjukhuset, ANOPIVA, Ing70, 2Tr, 75185, Uppsala, Sweden.
Jewish General Hospital · CAUppsala University · SEUppsala University Hospital · SEMcGill University · CADuke-NUS Medical School · SGDuke University Hospital · USFulcrum Therapeutics (United States) · US

Funding

CIHR CIHR: 365825Hjärt-Lungfonden 20210089, 20190639, 20190637Knut och Alice Wallenbergs Stiftelse KAW 2020.0182Svenska Läkaresällskapet SLS-938101Swedish Kidney Foundation F2020-0054Vetenskapsrådet 2014-02569, 2014-07606
6 · The paper itself

Abstract

backgroundWe have previously shown that iatrogenic dehydration is associated with a shift to organic osmolyte production in the general ICU population. The aim of the present investigation was to determine the validity of the physiological response to dehydration known as aestivation and its relevance for long-term disease outcome in COVID-19.

methodsThe study includes 374 COVID-19 patients from the Pronmed cohort admitted to the ICU at Uppsala University Hospital. Dehydration data was available for 165 of these patients and used for the primary analysis. Validation was performed in Biobanque Québécoise de la COVID-19 (BQC19) using 1052 patients with dehydration data. Dehydration was assessed through estimated osmolality (eOSM = 2Na + 2 K + glucose + urea), and correlated to important endpoints including death, invasive mechanical ventilation, acute kidney injury, and long COVID-19 symptom score grouped by physical or mental.

resultsIncreasing eOSM was correlated with increasing role of organic osmolytes for eOSM, while the proportion of sodium and potassium of eOSM were inversely correlated to eOSM. Acute outcomes were associated with pronounced dehydration, and physical long-COVID was more strongly associated with dehydration than mental long-COVID after adjustment for age, sex, and disease severity. Metabolomic analysis showed enrichment of amino acids among metabolites that showed an aestivating pattern.

conclusionsDehydration during acute COVID-19 infection causes an aestivation response that is associated with protein degradation and physical long-COVID.

trial registrationThe study was registered à priori (clinicaltrials.gov: NCT04316884 registered on 2020-03-13 and NCT04474249 registered on 2020-06-29).

Indexed as

COVID-19Amino AcidsDehydrationGlucoseHumansPost-Acute COVID-19 SyndromePotassiumSARS-CoV-2SodiumUreaAmino AcidsGlucosePotassiumSodiumUreaAcute kidney injuryAestivationIntensive care medicineLong-COVIDSARS-CoV-2Urea synthesis

Identifiers

PMID36271419
PMCPMC9585783
OpenAlexW4306969898

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.