ArticleBMC ophthalmology2022
Changes in retinal vascular bifurcation in eyes with myopia.
Article in BMC ophthalmology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 15 citations in OpenAlex.
- The Effects of Myopia on Optic Disc Morphology and Retinal Vascular Geometry: A Study of Anisometropic Eyes.Translational vision science & technology · 2026Article
- Chronic dental lighting disrupts blood-retinal barrier homeostasis via vascular and inflammatory pathways.International journal of oral science · 2026Article
- Artificial intelligence-based quantitative analysis of interocular retinal vascular differences in school-age children with mild to moderate anisometropia.Frontiers in medicine · 2026Article
- Artificial intelligence assisted quantitative analysis of fundus structural and vascular alterations reveals fundus tessellation as a robust biomarker of myopia severity.Frontiers in cell and developmental biology · 2026Article
- Retinal Vessel Geometry and Retinal Abnormalities in Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy.Translational vision science & technology · 2025Article
- Deep learning assisted retinal microvasculature assessment and cerebral small vessel disease in Fabry disease.Orphanet journal of rare diseases · 2025Article
- Myopia development: multifactorial interplay, molecular mechanisms and possible strategies.Frontiers in medicine · 2025Review
- Comparative analysis of retinal vascular structural parameters in populations with different glucose metabolism status based on color fundus photography and artificial intelligence.Frontiers in cell and developmental biology · 2025Article
- RBAD: A Dataset and Benchmark for Retinal Vessels Branching Angle Detection.... IEEE-EMBS International Conference on Biomedical and Health Informatics. IEEE-EMBS International Conference on Biomedical and Health Informatics · 2024Article
- AI-based fully automatic analysis of retinal vascular morphology in pediatric high myopia.BMC ophthalmology · 2024Article
- Analysis and comparison of retinal vascular parameters under different glucose metabolic status based on deep learning.International journal of ophthalmology · 2024Article
- Evidence of vascular involvement in myopia: a review.Frontiers in medicine · 2023Review
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo evaluate the effect of myopia on retinal vascular bifurcation.
methodsA cross-sectional study that retrospectively analyzed the fundus photographs and clinical data of 493 people who participated in routine physical examinations in Huadong Sanatorium. One eye of each subject was included in the analysis. Retinal vascular bifurcation measurements were extracted by using a validated computer program. One-way ANOVA and analysis of covariance were performed to compare the measurements across high myopia, low to moderate myopia, and non-myopia groups.
resultsThe mean age was 41.83 ± 10.43 years and 63.49% were women. The mean spherical equivalent refraction (SER) was - 4.59 ± 3.07 D. Ninety-nine (20.08%) eyes met the definition of high myopia (SER ≤ -6.0 D), along with 234 (47.46%) low to moderate myopia (-6.0 D < SER <-0.5 D), and 160 (32.45%) non-myopia (SER ≥ -0.5 D). The differences in the arteriolar branching angle, venular branching coefficient, venular asymmetry ratio, venular angular asymmetry, and venular junctional exponent among the three groups remained significant (p < 0.05) after multivariate adjustment. Pairwise comparisons showed arteriolar branching angle and venular angular asymmetry in high myopia were significantly lower than low to moderate myopia (p < 0.001, p = 0.014 respectively) and non-myopia (p = 0.007, p = 0.048 respectively). Venular asymmetry ratio and venular branching coefficient in high myopia were significantly higher than low to moderate myopia (p = 0.029, p = 0.001 respectively) and non-myopia (p = 0.041, p = 0.043 respectively). There was a significant difference in venular junctional exponent between high myopia and low to moderate myopia (p = 0.031).
conclusionThe vascular bifurcation differs in dependence on the myopic refractive error and a significant increase in the difference can be observed in high myopic eyes.
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