Evidence map›Paper›PMID 36271367›Full record

SynthesisBMC geriatrics2022

Efficacy and evaluation of therapeutic exercises on adults with Parkinson's disease: a systematic review and network meta-analysis.

Yong Yang, Guotuan Wang, Shikun Zhang, Huan Wang, Wensheng Zhou, Feifei Ren, Huimin Liang, Dongdong Wu, Xinying Ji, Makoto Hashimoto and 1 more

3 registry-linked trialsAbstract readSystematic ReviewNetwork Meta-Analysis
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in BMC geriatrics, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 3 registered trials, which are not on this map. Cited by 33 papers, 14 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 14 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07068217 nanot yet recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Metronome-Based Structured Rhythmic Exercise Program on Freezing and Gait Parameters in Parkinson Disease

TypeinterventionalSponsorMedipol UniversityRan2025 to 2026Enrolled26ConditionsPARKINSON DISEASE (Disorder)ArmsExercise
NCT07264114 nacompletednot on this mapstarted 2025, after this paper: background citation

The Effect of Aquatic High-Intensity Interval Training on Balance, Physical Function, and Sarcopenia in Patients With Parkinson's Disease: A Randomized Controlled Trial Protocol

TypeinterventionalSponsorPardis Specialized Wellness InstituteRan2025 to 2026Enrolled56ConditionsParkinson DiseaseArmsAquatic HIIT with adherence/support package
NCT07525973 naenrolling by invitationnot on this mapstarted 2026, after this paper: background citation

The Effect of Eye Exercises on Physical Function, Balance, and Fall Risk in Patients With Parkinson's Disease: A Randomized Controlled Trial

TypeinterventionalSponsorPardis Specialized Wellness InstituteRan2026 to 2026Enrolled34ConditionsParkinson DiseaseArmsSupervised In-Center Eye Exercises
3 · Its place in the literature

Who cites it

33 citing papers in PubMed, 14 syntheses or guidelines pooled it.

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  3. Optimal dose and type of exercise improve the overall balance in adults with Parkinson's disease: a systematic review and Bayesian network meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yong YangInstitute for Brain Sciences Research, School of Life Sciences, Shunhe District, Henan University, 85 Minglun Rd, Kaifeng City, 475001, China.
Guotuan WangLaboratory of Kinesiology and Rehabilitation, School of Physical Education and Sport, Henan University, Kaifeng, 475001, China.
Shikun ZhangDepartment of Police Physical Education, Jiangsu Police Institute, Nanjing, China.
Huan WangDepartment of Orthopedics, the Second Affiliated Hospital of Air Force Medical University, Xi 'an, China.
Wensheng ZhouCollege of Physical Education, Nanjing Xiao-Zhuang University, Nanjing, China.
Feifei RenDepartment of Physical Education, Beijing Language and Culture University, Beijing, China.
Huimin LiangInstitute for Brain Sciences Research, School of Life Sciences, Shunhe District, Henan University, 85 Minglun Rd, Kaifeng City, 475001, China.
Dongdong WuInstitute for Brain Sciences Research, School of Life Sciences, Shunhe District, Henan University, 85 Minglun Rd, Kaifeng City, 475001, China.
Xinying JiInstitute for Brain Sciences Research, School of Life Sciences, Shunhe District, Henan University, 85 Minglun Rd, Kaifeng City, 475001, China.
Makoto HashimotoTokyo Metropolitan Institute of Medical Science, Setagaya Ku, 2-1-6 Kamikitazawa, Tokyo, 1560057, Japan.
Jianshe WeiInstitute for Brain Sciences Research, School of Life Sciences, Shunhe District, Henan University, 85 Minglun Rd, Kaifeng City, 475001, China. jswei@henu.edu.cn.ORCID 0000-0002-3560-3392

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundExercises are an effective treatment in Parkinson's disease (PD), but there is still controversy over which types should be used. We aimed to compare and rank the types of exercise that improve PD symptoms by quantifying information from randomised controlled trials.

methodsWe performed a systematic review and network meta-analysis and searched PubMed, MEDLINE, Embase, PsycINFO, Cochrane Central Register of Controlled Trials (CENTRAL), Web of Science, and China National Knowledge Infrastructure (CNKI) from their inception date to June 30, 2022. We included randomized controlled trials of 24 types of exercise for the interventional treatment of adults (≥ 50 years old) with PD. Effect size measures were standardized mean differences (SMDs) with 95% credible intervals (CrIs). The confidence of evidence was examined using Confidence in Network Meta-Analysis (CINeMA).

resultsWe identified 10 474 citations and included 250 studies involving 13 011 participants. Results of NMA showed that power training (PT) had the best benefits for motor symptoms compared with the control group (CON), with SMDs (95% CrI) (-1.46, [-2.18 to -0.74]). Body weight support treadmill training (BWS_TT) showed the best improvement in balance (1.55, [0.72 to 2.37]), gait velocity (1.15 [0.57 to 1.31]) and walking distance (1.96, [1.18 to 2.73]), and robotic assisted gait training (RA_GT) had the most benefits for freezing of gait (-1.09, [-1.80 to -0.38]). For non-motor symptoms, Dance showed the best benefits for depression (-1.71, [-2.79 to -0.73]). Only Yoga significantly reduced anxiety symptom compared with CON (-0.53, [0.96 to -0.11]). Only resistance training (RT) significantly enhanced sleep quality and cognition (-1.42, [-2.60 to -0.23]; 0.51, [0.09 to 0.94]). For muscle strength, PT showed the best advance (1.04, [0.64 to 1.44]). For concern of falling, five types of exercise were more effective than CON.

conclusionsThere is low quality evidence that PT, Yoga, BWS_TT, Dance, and RT are the most effective treatments, pending outcome of interest, for adults with PD.

trial registrationPROSPERO (CRD42021220052).

Indexed as

Gait Disorders, NeurologicParkinson DiseaseExercise TherapyGaitHumansEvidence-based medicineExerciseParkinson' s diseasePhysical activityQuality of life

Identifiers

PMID36271367
PMCPMC9587576

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.