ArticleBMC microbiology2022
Whole genome sequencing of Moraxella bovis strains from North America reveals two genotypes with different genetic determinants.
Article in BMC microbiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 16 citations in OpenAlex.
- Moraxella tarda sp. nov., a Novel Species Isolated from Nasal Cavity of Cattle with Infectious Bovine Keratoconjunctivitis.Current microbiology · 2026Article
- The bovine ocular microbiome: a multi-approach study of composition and antimicrobial activity.Animal microbiome · 2026Article
- Identification of Polysialic Acid and Chondroitin-like Polysaccharides ofACS infectious diseases · 2026Article
- Genetic diversity, virulence genes, and antimicrobial resistance of Moraxella bovoculi and Moraxella bovis from infectious bovine keratoconjunctivitis: insights from MALDI-TOF-MS, 16S rRNA analyses, and other ocular bacteria.Veterinary research communications · 2025Article
- Bovine ocular microbiome: the next frontier in managing Pinkeye in cattle.Animal microbiome · 2025Article
- Targeted next-generation sequencing assay to detect 3Journal of veterinary diagnostic investigation : official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc · 2024Article
- Early detection of infectious bovine keratoconjunctivitis with artificial intelligence.Veterinary research · 2023Article
- Development and evaluation of a multiplex polymerase chain reaction in real-time for differential diagnosis ofVeterinary world · 2023Article
- Article
- Association of different microbes and pathogenic factors in cases of infectious bovine keratoconjunctivitis in cattle from Eastern Kazakhstan.Veterinary world · 2023Article
- Genotype classification ofFrontiers in microbiology · 2022Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMoraxella bovis and Moraxella bovoculi both associate with infectious bovine keratoconjunctivitis (IBK), an economically significant and painful ocular disease that affects cattle worldwide. There are two genotypes of M. bovoculi (genotypes 1 and 2) that differ in their gene content and potential virulence factors, although neither have been experimentally shown to cause IBK. M. bovis is a causative IBK agent, however, not all strains carry a complete assortment of known virulence factors. The goals of this study were to determine the population structure and depth of M. bovis genomic diversity, and to compare core and accessory genes and predicted outer membrane protein profiles both within and between M. bovis and M. bovoculi.
resultsPhylogenetic trees and bioinformatic analyses of 36 M. bovis chromosomes sequenced in this study and additional available chromosomes of M. bovis and both genotype 1 and 2 M. bovoculi, showed there are two genotypes (1 and 2) of M. bovis. The two M. bovis genotypes share a core of 2015 genes, with 121 and 186 genes specific to genotype 1 and 2, respectively. The two genotypes differ by their chromosome size and prophage content, encoded protein variants of the virulence factor hemolysin, and by their affiliation with different plasmids. Eight plasmid types were identified in this study, with types 1 and 6 observed in 88 and 56% of genotype 2 strains, respectively, and absent from genotype 1 strains. Only type 1 plasmids contained one or two gene copies encoding filamentous haemagglutinin-like proteins potentially involved with adhesion. A core of 1403 genes was shared between the genotype 1 and 2 strains of both M. bovis and M. bovoculi, which encoded a total of nine predicted outer membrane proteins.
conclusionsThere are two genotypes of M. bovis that differ in both chromosome content and plasmid profiles and thus may not equally associate with IBK. Immunological reagents specifically targeting select genotypes of M. bovis, or all genotypes of M. bovis and M. bovoculi together could be designed from the outer membrane proteins identified in this study.
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