ArticleNature communications2022
Temporally programmed polymer - solvent interactions using a chemical reaction network.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Bioelectrochemically Powered Out-of-Equilibrium Hydrogels Enable Feedback-Regulated Functions.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pathway selection between click and acyl transfer reactions driven by aminoacyl phosphates.Nature communications · 2026Article
- Tailored Phosphate Leaving Groups Direct Pathway-Dependent Self-Assembly.Journal of the American Chemical Society · 2026Article
- Nucleophile-triggered prodrug release from polymer hydrogels.RSC applied polymers · 2026Article
- Photoactivated Enzymatic Reaction Network Enables Spatiotemporal Programming of Thiol/Disulfide Redox Systems.Angewandte Chemie (International ed. in English) · 2025Article
- Hydration Effects Driving Network Remodeling in Hydrogels during Cyclic Loading.ACS macro letters · 2025Article
- Feedback driven autonomous cycles of assembly and disassembly from minimal building blocks.Nature communications · 2024Article
- Vitrimer-like elastomers with rapid stress-relaxation by high-speed carboxy exchange through conjugate substitution reaction.Nature communications · 2024Article
- Kinetically Controlled and Nonequilibrium Assembly of Block Copolymers in Solution.Journal of the American Chemical Society · 2024Review
- Naked-Eye Thiol Analyte Detection via Self-Propagating, Amplified Reaction Cycle.Journal of the American Chemical Society · 2023Article
- Chemical reaction networks based on conjugate additions on β'-substituted Michael acceptors.Chemical communications (Cambridge, England) · 2023Review
- Redox-Controlled Shunts in a Synthetic Chemical Reaction Cycle.Journal of the American Chemical Society · 2023Article
- Nucleophile responsive charge-reversing polycations for pDNA transfection.Polymer chemistry · 2023Article
- Chemical signal regulated injectable coacervate hydrogels.Chemical science · 2023Article
- Temporally programmed polymer - solvent interactions using a chemical reaction network.Nature communications · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Out of equilibrium operation of chemical reaction networks (CRNs) enables artificial materials to autonomously respond to their environment by activation and deactivation of intermolecular interactions. Generally, their activation can be driven by various chemical conversions, yet their deactivation to non-interacting building blocks remains largely limited to hydrolysis and internal pH change. To achieve control over deactivation, we present a new, modular CRN that enables reversible formation of positive charges on a tertiary amine substrate, which are removed using nucleophilic signals that control the deactivation kinetics. The modular nature of the CRN enables incorporation in diverse polymer materials, leading to a temporally programmed transition from collapsed and hydrophobic to solvated, hydrophilic polymer chains by controlling polymer-solvent interactions. Depending on the layout of the CRN, we can create stimuli-responsive or autonomously responding materials. This concept will not only offer new opportunities in molecular cargo delivery but also pave the way for next-generation interactive materials.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.